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Increased Risk for Cerebral Hypoxia During Immediate Neonatal Transition After Birth in Term Neonates Delivered by Caesarean Section With Prenatal Tobacco Exposure

Introduction: Maternal tobacco smoking during pregnancy is a global health problem leading to an increased risk for fetal and neonatal morbidities. So far, there are no data of the potential impact of maternal smoking during pregnancy on the most vulnerable period after birth – the immediate postnat...

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Autores principales: Wolfsberger, Christina Helene, Bruckner, Marlies, Schwaberger, Bernhard, Mileder, Lukas Peter, Pritisanac, Ena, Hoeller, Nina, Avian, Alexander, Urlesberger, Berndt, Pichler, Gerhard
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8650081/
https://www.ncbi.nlm.nih.gov/pubmed/34888265
http://dx.doi.org/10.3389/fped.2021.747509
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author Wolfsberger, Christina Helene
Bruckner, Marlies
Schwaberger, Bernhard
Mileder, Lukas Peter
Pritisanac, Ena
Hoeller, Nina
Avian, Alexander
Urlesberger, Berndt
Pichler, Gerhard
author_facet Wolfsberger, Christina Helene
Bruckner, Marlies
Schwaberger, Bernhard
Mileder, Lukas Peter
Pritisanac, Ena
Hoeller, Nina
Avian, Alexander
Urlesberger, Berndt
Pichler, Gerhard
author_sort Wolfsberger, Christina Helene
collection PubMed
description Introduction: Maternal tobacco smoking during pregnancy is a global health problem leading to an increased risk for fetal and neonatal morbidities. So far, there are no data of the potential impact of maternal smoking during pregnancy on the most vulnerable period after birth – the immediate postnatal transition. The aim of the present study was therefore, to compare cerebral oxygenation during immediate postnatal transition in term neonates with and without prenatal tobacco exposure. Methods: Included in this post-hoc analysis were healthy term neonates, with measurements of cerebral oxygenation (INVOS 5100C) during the first 15 min after birth, and for whom information on maternal smoking behavior during pregnancy was available. Neonates with prenatal tobacco exposure (smoking group) were matched 1:1 according to gestational age (±1 week), birth weight (±100 grams) and hematocrit (±5 %) to neonates without (non-smoking group). Cerebral regional tissue oxygen saturation (crSO(2)), cerebral fractional tissue oxygen extraction (cFTOE), arterial oxygen saturation (SpO(2)) and heart rate (HR) within the first 15 min after birth were compared between the two groups. Results: Twelve neonates in the smoking group with a median (IQR) gestational age of 39.1 (38.8–39.3) weeks and a birth weight of 3,155 (2,970–3,472) grams were compared to 12 neonates in the non-smoking group with 39.1 (38.7–39.2) weeks and 3,134 (2,963–3,465) grams. In the smoking group, crSO(2) was significantly lower and cFTOE significantly higher until min 5 after birth. HR was significantly higher in the smoking group in min 3 after birth. Beyond this period, there were no significant differences between the two groups. Conclusion: Cerebral oxygenation within the first 5 min after birth was compromised in neonates with prenatal tobacco exposure. This observation suggests a higher risk for cerebral hypoxia immediately after birth due to fetal tobacco exposure.
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spelling pubmed-86500812021-12-08 Increased Risk for Cerebral Hypoxia During Immediate Neonatal Transition After Birth in Term Neonates Delivered by Caesarean Section With Prenatal Tobacco Exposure Wolfsberger, Christina Helene Bruckner, Marlies Schwaberger, Bernhard Mileder, Lukas Peter Pritisanac, Ena Hoeller, Nina Avian, Alexander Urlesberger, Berndt Pichler, Gerhard Front Pediatr Pediatrics Introduction: Maternal tobacco smoking during pregnancy is a global health problem leading to an increased risk for fetal and neonatal morbidities. So far, there are no data of the potential impact of maternal smoking during pregnancy on the most vulnerable period after birth – the immediate postnatal transition. The aim of the present study was therefore, to compare cerebral oxygenation during immediate postnatal transition in term neonates with and without prenatal tobacco exposure. Methods: Included in this post-hoc analysis were healthy term neonates, with measurements of cerebral oxygenation (INVOS 5100C) during the first 15 min after birth, and for whom information on maternal smoking behavior during pregnancy was available. Neonates with prenatal tobacco exposure (smoking group) were matched 1:1 according to gestational age (±1 week), birth weight (±100 grams) and hematocrit (±5 %) to neonates without (non-smoking group). Cerebral regional tissue oxygen saturation (crSO(2)), cerebral fractional tissue oxygen extraction (cFTOE), arterial oxygen saturation (SpO(2)) and heart rate (HR) within the first 15 min after birth were compared between the two groups. Results: Twelve neonates in the smoking group with a median (IQR) gestational age of 39.1 (38.8–39.3) weeks and a birth weight of 3,155 (2,970–3,472) grams were compared to 12 neonates in the non-smoking group with 39.1 (38.7–39.2) weeks and 3,134 (2,963–3,465) grams. In the smoking group, crSO(2) was significantly lower and cFTOE significantly higher until min 5 after birth. HR was significantly higher in the smoking group in min 3 after birth. Beyond this period, there were no significant differences between the two groups. Conclusion: Cerebral oxygenation within the first 5 min after birth was compromised in neonates with prenatal tobacco exposure. This observation suggests a higher risk for cerebral hypoxia immediately after birth due to fetal tobacco exposure. Frontiers Media S.A. 2021-11-23 /pmc/articles/PMC8650081/ /pubmed/34888265 http://dx.doi.org/10.3389/fped.2021.747509 Text en Copyright © 2021 Wolfsberger, Bruckner, Schwaberger, Mileder, Pritisanac, Hoeller, Avian, Urlesberger and Pichler. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Pediatrics
Wolfsberger, Christina Helene
Bruckner, Marlies
Schwaberger, Bernhard
Mileder, Lukas Peter
Pritisanac, Ena
Hoeller, Nina
Avian, Alexander
Urlesberger, Berndt
Pichler, Gerhard
Increased Risk for Cerebral Hypoxia During Immediate Neonatal Transition After Birth in Term Neonates Delivered by Caesarean Section With Prenatal Tobacco Exposure
title Increased Risk for Cerebral Hypoxia During Immediate Neonatal Transition After Birth in Term Neonates Delivered by Caesarean Section With Prenatal Tobacco Exposure
title_full Increased Risk for Cerebral Hypoxia During Immediate Neonatal Transition After Birth in Term Neonates Delivered by Caesarean Section With Prenatal Tobacco Exposure
title_fullStr Increased Risk for Cerebral Hypoxia During Immediate Neonatal Transition After Birth in Term Neonates Delivered by Caesarean Section With Prenatal Tobacco Exposure
title_full_unstemmed Increased Risk for Cerebral Hypoxia During Immediate Neonatal Transition After Birth in Term Neonates Delivered by Caesarean Section With Prenatal Tobacco Exposure
title_short Increased Risk for Cerebral Hypoxia During Immediate Neonatal Transition After Birth in Term Neonates Delivered by Caesarean Section With Prenatal Tobacco Exposure
title_sort increased risk for cerebral hypoxia during immediate neonatal transition after birth in term neonates delivered by caesarean section with prenatal tobacco exposure
topic Pediatrics
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8650081/
https://www.ncbi.nlm.nih.gov/pubmed/34888265
http://dx.doi.org/10.3389/fped.2021.747509
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