Regioselective Monoborylation of Spirocyclobutenes

[Image: see text] We present a strategy for the synthesis of spirocyclic cyclobutanes with modulable exit vectors based on the regioselective monoborylation of spirocyclobutenes. Using an inexpensive copper salt and a commercially available bidentate phosphine, a broad variety of borylated spirocycl...

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Autores principales: Nóvoa, Luis, Trulli, Laura, Fernández, Israel, Parra, Alejandro, Tortosa, Mariola
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2021
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8650097/
https://www.ncbi.nlm.nih.gov/pubmed/34524833
http://dx.doi.org/10.1021/acs.orglett.1c02645
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author Nóvoa, Luis
Trulli, Laura
Fernández, Israel
Parra, Alejandro
Tortosa, Mariola
author_facet Nóvoa, Luis
Trulli, Laura
Fernández, Israel
Parra, Alejandro
Tortosa, Mariola
author_sort Nóvoa, Luis
collection PubMed
description [Image: see text] We present a strategy for the synthesis of spirocyclic cyclobutanes with modulable exit vectors based on the regioselective monoborylation of spirocyclobutenes. Using an inexpensive copper salt and a commercially available bidentate phosphine, a broad variety of borylated spirocycles have been prepared with complete regiocontrol. The boryl moiety provides a synthetic handled for further functionalization, allowing access to a wide array of spirocyclic building blocks from a common intermediate.
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spelling pubmed-86500972021-12-08 Regioselective Monoborylation of Spirocyclobutenes Nóvoa, Luis Trulli, Laura Fernández, Israel Parra, Alejandro Tortosa, Mariola Org Lett [Image: see text] We present a strategy for the synthesis of spirocyclic cyclobutanes with modulable exit vectors based on the regioselective monoborylation of spirocyclobutenes. Using an inexpensive copper salt and a commercially available bidentate phosphine, a broad variety of borylated spirocycles have been prepared with complete regiocontrol. The boryl moiety provides a synthetic handled for further functionalization, allowing access to a wide array of spirocyclic building blocks from a common intermediate. American Chemical Society 2021-09-15 2021-10-01 /pmc/articles/PMC8650097/ /pubmed/34524833 http://dx.doi.org/10.1021/acs.orglett.1c02645 Text en © 2021 American Chemical Society https://creativecommons.org/licenses/by/4.0/Permits the broadest form of re-use including for commercial purposes, provided that author attribution and integrity are maintained (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Nóvoa, Luis
Trulli, Laura
Fernández, Israel
Parra, Alejandro
Tortosa, Mariola
Regioselective Monoborylation of Spirocyclobutenes
title Regioselective Monoborylation of Spirocyclobutenes
title_full Regioselective Monoborylation of Spirocyclobutenes
title_fullStr Regioselective Monoborylation of Spirocyclobutenes
title_full_unstemmed Regioselective Monoborylation of Spirocyclobutenes
title_short Regioselective Monoborylation of Spirocyclobutenes
title_sort regioselective monoborylation of spirocyclobutenes
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8650097/
https://www.ncbi.nlm.nih.gov/pubmed/34524833
http://dx.doi.org/10.1021/acs.orglett.1c02645
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