Cargando…

Hospitalizations related to meningococcal infection in Spain from 1997 to 2018

BACKGROUND: Baseline hospitalization, mortality, and in-hospital fatality rates for meningococcal infection are required to evaluate preventive interventions, such as the inclusion of the conjugated quadrivalent meningococcal vaccine and serogroup B based protein vaccines. METHODS: All meningococcal...

Descripción completa

Detalles Bibliográficos
Autores principales: Walter, Stefan, Gil-Prieto, Ruth, Gil-Conesa, Mario, Rodriguez-Caravaca, Gil, San Román, Jesús, Gil de Miguel, Angel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8650227/
https://www.ncbi.nlm.nih.gov/pubmed/34872512
http://dx.doi.org/10.1186/s12879-021-06916-9
_version_ 1784611155939950592
author Walter, Stefan
Gil-Prieto, Ruth
Gil-Conesa, Mario
Rodriguez-Caravaca, Gil
San Román, Jesús
Gil de Miguel, Angel
author_facet Walter, Stefan
Gil-Prieto, Ruth
Gil-Conesa, Mario
Rodriguez-Caravaca, Gil
San Román, Jesús
Gil de Miguel, Angel
author_sort Walter, Stefan
collection PubMed
description BACKGROUND: Baseline hospitalization, mortality, and in-hospital fatality rates for meningococcal infection are required to evaluate preventive interventions, such as the inclusion of the conjugated quadrivalent meningococcal vaccine and serogroup B based protein vaccines. METHODS: All meningococcal infection–related hospitalizations in any diagnostic position in Spain from 1st January 1997 through 31st December 2018 were analysed. The annual hospitalization rate, mortality rate and case-fatality rate were calculated. RESULTS: The average hospitalization rate for meningococcal infection was 1.64 (95% CI 1.61 to 1.66) hospitalizations per 100,000 inhabitants during the study period and significantly decreased from 1997 to 2018. Hospitalizations for meningococcal infection decreased significantly with age and were concentrated in children under 5 years of age (46%). The hospitalization rates reached 29 per 100,000 and 24 per 100,000 children under 1 and 2 years of age, respectively. The in-hospital case-fatality rate was 7.45% (95% CI 7.03 to 7.86). Thirty percent of the deaths occurred in children under 5 years of age, and more than half occurred in adults. The case fatality rate increased significantly with age (p < 0.001). CONCLUSION: It is necessary to maintain epidemiological surveillance of meningococcal infection to determine the main circulating serogroups involved, track their evolution, and evaluate preventive measures whose effectiveness must be assessed in all age groups.
format Online
Article
Text
id pubmed-8650227
institution National Center for Biotechnology Information
language English
publishDate 2021
publisher BioMed Central
record_format MEDLINE/PubMed
spelling pubmed-86502272021-12-07 Hospitalizations related to meningococcal infection in Spain from 1997 to 2018 Walter, Stefan Gil-Prieto, Ruth Gil-Conesa, Mario Rodriguez-Caravaca, Gil San Román, Jesús Gil de Miguel, Angel BMC Infect Dis Research BACKGROUND: Baseline hospitalization, mortality, and in-hospital fatality rates for meningococcal infection are required to evaluate preventive interventions, such as the inclusion of the conjugated quadrivalent meningococcal vaccine and serogroup B based protein vaccines. METHODS: All meningococcal infection–related hospitalizations in any diagnostic position in Spain from 1st January 1997 through 31st December 2018 were analysed. The annual hospitalization rate, mortality rate and case-fatality rate were calculated. RESULTS: The average hospitalization rate for meningococcal infection was 1.64 (95% CI 1.61 to 1.66) hospitalizations per 100,000 inhabitants during the study period and significantly decreased from 1997 to 2018. Hospitalizations for meningococcal infection decreased significantly with age and were concentrated in children under 5 years of age (46%). The hospitalization rates reached 29 per 100,000 and 24 per 100,000 children under 1 and 2 years of age, respectively. The in-hospital case-fatality rate was 7.45% (95% CI 7.03 to 7.86). Thirty percent of the deaths occurred in children under 5 years of age, and more than half occurred in adults. The case fatality rate increased significantly with age (p < 0.001). CONCLUSION: It is necessary to maintain epidemiological surveillance of meningococcal infection to determine the main circulating serogroups involved, track their evolution, and evaluate preventive measures whose effectiveness must be assessed in all age groups. BioMed Central 2021-12-06 /pmc/articles/PMC8650227/ /pubmed/34872512 http://dx.doi.org/10.1186/s12879-021-06916-9 Text en © The Author(s) 2021 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
spellingShingle Research
Walter, Stefan
Gil-Prieto, Ruth
Gil-Conesa, Mario
Rodriguez-Caravaca, Gil
San Román, Jesús
Gil de Miguel, Angel
Hospitalizations related to meningococcal infection in Spain from 1997 to 2018
title Hospitalizations related to meningococcal infection in Spain from 1997 to 2018
title_full Hospitalizations related to meningococcal infection in Spain from 1997 to 2018
title_fullStr Hospitalizations related to meningococcal infection in Spain from 1997 to 2018
title_full_unstemmed Hospitalizations related to meningococcal infection in Spain from 1997 to 2018
title_short Hospitalizations related to meningococcal infection in Spain from 1997 to 2018
title_sort hospitalizations related to meningococcal infection in spain from 1997 to 2018
topic Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8650227/
https://www.ncbi.nlm.nih.gov/pubmed/34872512
http://dx.doi.org/10.1186/s12879-021-06916-9
work_keys_str_mv AT walterstefan hospitalizationsrelatedtomeningococcalinfectioninspainfrom1997to2018
AT gilprietoruth hospitalizationsrelatedtomeningococcalinfectioninspainfrom1997to2018
AT gilconesamario hospitalizationsrelatedtomeningococcalinfectioninspainfrom1997to2018
AT rodriguezcaravacagil hospitalizationsrelatedtomeningococcalinfectioninspainfrom1997to2018
AT sanromanjesus hospitalizationsrelatedtomeningococcalinfectioninspainfrom1997to2018
AT gildemiguelangel hospitalizationsrelatedtomeningococcalinfectioninspainfrom1997to2018