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Maternal Anxiety and Infants Birthweight and Length of Gestation. A sibling design

BACKGROUND: The overall aim of this study is to examine the effect of prenatal maternal anxiety on birthweight and gestational age, controlling for shared family confounding using a sibling comparison design. METHODS: The data on 77,970 mothers and their 91,165 children from the population-based Mot...

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Autores principales: Bekkhus, Mona, Lee, Yunsung, Brandlistuen, Ragnhild Eek, Samuelsen, Sven Ove, Magnus, Per
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8650251/
https://www.ncbi.nlm.nih.gov/pubmed/34876072
http://dx.doi.org/10.1186/s12888-021-03620-5
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author Bekkhus, Mona
Lee, Yunsung
Brandlistuen, Ragnhild Eek
Samuelsen, Sven Ove
Magnus, Per
author_facet Bekkhus, Mona
Lee, Yunsung
Brandlistuen, Ragnhild Eek
Samuelsen, Sven Ove
Magnus, Per
author_sort Bekkhus, Mona
collection PubMed
description BACKGROUND: The overall aim of this study is to examine the effect of prenatal maternal anxiety on birthweight and gestational age, controlling for shared family confounding using a sibling comparison design. METHODS: The data on 77,970 mothers and their 91,165 children from the population-based Mother, Father and Child Cohort Study and data on 12,480 pairs of siblings were used in this study. The mothers filled out questionnaires for each unique pregnancy, at 17(th) and 30(th) week in pregnancy. Gestational age and birth weight was extracted from the Medical Birth Registry of Norway (MBRN). Associations between prenatal maternal anxiety (measured across the 17(th) and 30(th) weeks) and birth outcomes (birthweight and gestational age) were examined using linear regression with adjustment for shared-family confounding in a sibling comparison design. RESULTS: In the population level analysis the maternal anxiety score during pregnancy was inversely associated with new-born’s birthweight (Beta = -63.8 95% CI: -92.6, -35.0) and gestational age (Beta = -1.52, 95% CI: -2.15, -0.89) after adjustment for several covariates. The association of the maternal anxiety score with birthweight was no longer significant, but remained for maternal anxiety at 30(th) week with gestational age (Beta = -1.11, 95% CI: -1.82, -0.4) after further adjusting for the shared-family confounding in the sibling comparison design. CONCLUSION: No association was found for maternal prenatal anxiety with birth weight after multiple covariates and family environment were controlled. However, there was an association between prenatal maternal anxiety at 30(th) week only with gestational age, suggesting a timing effect for maternal anxiety in third trimester.
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spelling pubmed-86502512021-12-07 Maternal Anxiety and Infants Birthweight and Length of Gestation. A sibling design Bekkhus, Mona Lee, Yunsung Brandlistuen, Ragnhild Eek Samuelsen, Sven Ove Magnus, Per BMC Psychiatry Research BACKGROUND: The overall aim of this study is to examine the effect of prenatal maternal anxiety on birthweight and gestational age, controlling for shared family confounding using a sibling comparison design. METHODS: The data on 77,970 mothers and their 91,165 children from the population-based Mother, Father and Child Cohort Study and data on 12,480 pairs of siblings were used in this study. The mothers filled out questionnaires for each unique pregnancy, at 17(th) and 30(th) week in pregnancy. Gestational age and birth weight was extracted from the Medical Birth Registry of Norway (MBRN). Associations between prenatal maternal anxiety (measured across the 17(th) and 30(th) weeks) and birth outcomes (birthweight and gestational age) were examined using linear regression with adjustment for shared-family confounding in a sibling comparison design. RESULTS: In the population level analysis the maternal anxiety score during pregnancy was inversely associated with new-born’s birthweight (Beta = -63.8 95% CI: -92.6, -35.0) and gestational age (Beta = -1.52, 95% CI: -2.15, -0.89) after adjustment for several covariates. The association of the maternal anxiety score with birthweight was no longer significant, but remained for maternal anxiety at 30(th) week with gestational age (Beta = -1.11, 95% CI: -1.82, -0.4) after further adjusting for the shared-family confounding in the sibling comparison design. CONCLUSION: No association was found for maternal prenatal anxiety with birth weight after multiple covariates and family environment were controlled. However, there was an association between prenatal maternal anxiety at 30(th) week only with gestational age, suggesting a timing effect for maternal anxiety in third trimester. BioMed Central 2021-12-07 /pmc/articles/PMC8650251/ /pubmed/34876072 http://dx.doi.org/10.1186/s12888-021-03620-5 Text en © The Author(s) 2021 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
spellingShingle Research
Bekkhus, Mona
Lee, Yunsung
Brandlistuen, Ragnhild Eek
Samuelsen, Sven Ove
Magnus, Per
Maternal Anxiety and Infants Birthweight and Length of Gestation. A sibling design
title Maternal Anxiety and Infants Birthweight and Length of Gestation. A sibling design
title_full Maternal Anxiety and Infants Birthweight and Length of Gestation. A sibling design
title_fullStr Maternal Anxiety and Infants Birthweight and Length of Gestation. A sibling design
title_full_unstemmed Maternal Anxiety and Infants Birthweight and Length of Gestation. A sibling design
title_short Maternal Anxiety and Infants Birthweight and Length of Gestation. A sibling design
title_sort maternal anxiety and infants birthweight and length of gestation. a sibling design
topic Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8650251/
https://www.ncbi.nlm.nih.gov/pubmed/34876072
http://dx.doi.org/10.1186/s12888-021-03620-5
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