Optimization of metabolism to improve efficacy during CAR-T cell manufacturing

Chimeric antigen receptor T cell (CAR-T cell) therapy is a relatively new, effective, and rapidly evolving therapeutic for adoptive immunotherapies. Although it has achieved remarkable effect in hematological malignancies, there are some problems that remain to be resolved. For example, there are hi...

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Autores principales: Zhang, Meng, Jin, Xin, Sun, Rui, Xiong, Xia, Wang, Jiaxi, Xie, Danni, Zhao, MingFeng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2021
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8650271/
https://www.ncbi.nlm.nih.gov/pubmed/34876185
http://dx.doi.org/10.1186/s12967-021-03165-x
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author Zhang, Meng
Jin, Xin
Sun, Rui
Xiong, Xia
Wang, Jiaxi
Xie, Danni
Zhao, MingFeng
author_facet Zhang, Meng
Jin, Xin
Sun, Rui
Xiong, Xia
Wang, Jiaxi
Xie, Danni
Zhao, MingFeng
author_sort Zhang, Meng
collection PubMed
description Chimeric antigen receptor T cell (CAR-T cell) therapy is a relatively new, effective, and rapidly evolving therapeutic for adoptive immunotherapies. Although it has achieved remarkable effect in hematological malignancies, there are some problems that remain to be resolved. For example, there are high recurrence rates and poor efficacy in solid tumors. In this review, we first briefly describe the metabolic re-editing of T cells and the changes in metabolism during the preparation of CAR-T cells. Furthermore, we summarize the latest developments and newest strategies to improve the metabolic adaptability and antitumor activity of CAR-T cells in vitro and in vivo.
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spelling pubmed-86502712021-12-07 Optimization of metabolism to improve efficacy during CAR-T cell manufacturing Zhang, Meng Jin, Xin Sun, Rui Xiong, Xia Wang, Jiaxi Xie, Danni Zhao, MingFeng J Transl Med Review Chimeric antigen receptor T cell (CAR-T cell) therapy is a relatively new, effective, and rapidly evolving therapeutic for adoptive immunotherapies. Although it has achieved remarkable effect in hematological malignancies, there are some problems that remain to be resolved. For example, there are high recurrence rates and poor efficacy in solid tumors. In this review, we first briefly describe the metabolic re-editing of T cells and the changes in metabolism during the preparation of CAR-T cells. Furthermore, we summarize the latest developments and newest strategies to improve the metabolic adaptability and antitumor activity of CAR-T cells in vitro and in vivo. BioMed Central 2021-12-07 /pmc/articles/PMC8650271/ /pubmed/34876185 http://dx.doi.org/10.1186/s12967-021-03165-x Text en © The Author(s) 2021 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
spellingShingle Review
Zhang, Meng
Jin, Xin
Sun, Rui
Xiong, Xia
Wang, Jiaxi
Xie, Danni
Zhao, MingFeng
Optimization of metabolism to improve efficacy during CAR-T cell manufacturing
title Optimization of metabolism to improve efficacy during CAR-T cell manufacturing
title_full Optimization of metabolism to improve efficacy during CAR-T cell manufacturing
title_fullStr Optimization of metabolism to improve efficacy during CAR-T cell manufacturing
title_full_unstemmed Optimization of metabolism to improve efficacy during CAR-T cell manufacturing
title_short Optimization of metabolism to improve efficacy during CAR-T cell manufacturing
title_sort optimization of metabolism to improve efficacy during car-t cell manufacturing
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8650271/
https://www.ncbi.nlm.nih.gov/pubmed/34876185
http://dx.doi.org/10.1186/s12967-021-03165-x
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