Cargando…

Clinical relevance of glomerular IgM deposition in patients with lupus nephritis

BACKGROUND: The aim of the study was to investigate the clinical relevance of IgM deposition in patients with lupus nephritis (LN) in a large cohort. RESULTS: 217 patients with renal biopsy-proven active LN were enrolled. The associations between glomerular IgM deposition and clinicopathological par...

Descripción completa

Detalles Bibliográficos
Autores principales: Wang, Fengmei, Yu, Jirong, Zhang, Lei, Zhang, Yan, Zhang, Jie, Liu, Bicheng, Yang, Xiaowei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8650561/
https://www.ncbi.nlm.nih.gov/pubmed/34876020
http://dx.doi.org/10.1186/s12865-021-00467-z
_version_ 1784611223842586624
author Wang, Fengmei
Yu, Jirong
Zhang, Lei
Zhang, Yan
Zhang, Jie
Liu, Bicheng
Yang, Xiaowei
author_facet Wang, Fengmei
Yu, Jirong
Zhang, Lei
Zhang, Yan
Zhang, Jie
Liu, Bicheng
Yang, Xiaowei
author_sort Wang, Fengmei
collection PubMed
description BACKGROUND: The aim of the study was to investigate the clinical relevance of IgM deposition in patients with lupus nephritis (LN) in a large cohort. RESULTS: 217 patients with renal biopsy-proven active LN were enrolled. The associations between glomerular IgM deposition and clinicopathological parameters were further analyzed. IgM deposition was positively correlated with glomerular C1q and C3 deposition moderately (r = 0.436, P < 0.001; r = 0.408, P < 0.001, respectively), and inversely correlated with plasma levels of C3 and CFH mildly (r =  − 0.138, P = 0.043; r =  − 0.147, P = 0.037, respectively). By multivariate analysis, we found that glomerular IgM deposition independently contributed to glomerular C3 deposition in patients with LN (OR = 2.002, 95% CI 1.295–3.094, P = 0.002). In addition, we also found that patients with IgM 0–2+ had similar plasma CFH levels, but in patients with IgM3+–4+, plasma CFH levels were significantly lower (300.4 ± 155.8 μg/mL vs. 429.9 ± 187.5 μg/mL, P < 0.001). Furthermore, patients with high density of glomerular IgM and low levels of CFH had heavier proteinuria, higher serum creatinine and lower plasma C3 levels (5.7 ± 3.1 g/d vs. 4.7 ± 3.5 g/d, P = 0.037; 150.1 ± 121.0 μmol/L vs. 105.6 ± 97.1 μmol/L, P = 0.005; 0.3 ± 0.2 μg/L vs. 0.4 ± 0.2 μg/L, P = 0.04, respectively), comparing with those with low density of glomerular IgM and low levels of CFH. CONCLUSIONS: Our results suggested the involvement of glomerular deposited IgM in complement activation and renal injury in LN.
format Online
Article
Text
id pubmed-8650561
institution National Center for Biotechnology Information
language English
publishDate 2021
publisher BioMed Central
record_format MEDLINE/PubMed
spelling pubmed-86505612021-12-08 Clinical relevance of glomerular IgM deposition in patients with lupus nephritis Wang, Fengmei Yu, Jirong Zhang, Lei Zhang, Yan Zhang, Jie Liu, Bicheng Yang, Xiaowei BMC Immunol Research BACKGROUND: The aim of the study was to investigate the clinical relevance of IgM deposition in patients with lupus nephritis (LN) in a large cohort. RESULTS: 217 patients with renal biopsy-proven active LN were enrolled. The associations between glomerular IgM deposition and clinicopathological parameters were further analyzed. IgM deposition was positively correlated with glomerular C1q and C3 deposition moderately (r = 0.436, P < 0.001; r = 0.408, P < 0.001, respectively), and inversely correlated with plasma levels of C3 and CFH mildly (r =  − 0.138, P = 0.043; r =  − 0.147, P = 0.037, respectively). By multivariate analysis, we found that glomerular IgM deposition independently contributed to glomerular C3 deposition in patients with LN (OR = 2.002, 95% CI 1.295–3.094, P = 0.002). In addition, we also found that patients with IgM 0–2+ had similar plasma CFH levels, but in patients with IgM3+–4+, plasma CFH levels were significantly lower (300.4 ± 155.8 μg/mL vs. 429.9 ± 187.5 μg/mL, P < 0.001). Furthermore, patients with high density of glomerular IgM and low levels of CFH had heavier proteinuria, higher serum creatinine and lower plasma C3 levels (5.7 ± 3.1 g/d vs. 4.7 ± 3.5 g/d, P = 0.037; 150.1 ± 121.0 μmol/L vs. 105.6 ± 97.1 μmol/L, P = 0.005; 0.3 ± 0.2 μg/L vs. 0.4 ± 0.2 μg/L, P = 0.04, respectively), comparing with those with low density of glomerular IgM and low levels of CFH. CONCLUSIONS: Our results suggested the involvement of glomerular deposited IgM in complement activation and renal injury in LN. BioMed Central 2021-12-07 /pmc/articles/PMC8650561/ /pubmed/34876020 http://dx.doi.org/10.1186/s12865-021-00467-z Text en © The Author(s) 2021 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
spellingShingle Research
Wang, Fengmei
Yu, Jirong
Zhang, Lei
Zhang, Yan
Zhang, Jie
Liu, Bicheng
Yang, Xiaowei
Clinical relevance of glomerular IgM deposition in patients with lupus nephritis
title Clinical relevance of glomerular IgM deposition in patients with lupus nephritis
title_full Clinical relevance of glomerular IgM deposition in patients with lupus nephritis
title_fullStr Clinical relevance of glomerular IgM deposition in patients with lupus nephritis
title_full_unstemmed Clinical relevance of glomerular IgM deposition in patients with lupus nephritis
title_short Clinical relevance of glomerular IgM deposition in patients with lupus nephritis
title_sort clinical relevance of glomerular igm deposition in patients with lupus nephritis
topic Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8650561/
https://www.ncbi.nlm.nih.gov/pubmed/34876020
http://dx.doi.org/10.1186/s12865-021-00467-z
work_keys_str_mv AT wangfengmei clinicalrelevanceofglomerularigmdepositioninpatientswithlupusnephritis
AT yujirong clinicalrelevanceofglomerularigmdepositioninpatientswithlupusnephritis
AT zhanglei clinicalrelevanceofglomerularigmdepositioninpatientswithlupusnephritis
AT zhangyan clinicalrelevanceofglomerularigmdepositioninpatientswithlupusnephritis
AT zhangjie clinicalrelevanceofglomerularigmdepositioninpatientswithlupusnephritis
AT liubicheng clinicalrelevanceofglomerularigmdepositioninpatientswithlupusnephritis
AT yangxiaowei clinicalrelevanceofglomerularigmdepositioninpatientswithlupusnephritis