In Sickness and in Health: The Oxygen Reactive Species and the Bone

Oxidative stress plays a central role in physiological and pathological bone conditions. Its role in signalment and control of bone cell population differentiation, activity, and fate is increasingly recognized. The possibilities of its use and manipulation with therapeutic goals are virtually unend...

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Detalles Bibliográficos
Autores principales: Reis, Joana, Ramos, António
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Bioengineering and Biotechnology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8650620/
https://www.ncbi.nlm.nih.gov/pubmed/34888300
http://dx.doi.org/10.3389/fbioe.2021.745911
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author Reis, Joana
Ramos, António
author_facet Reis, Joana
Ramos, António
author_sort Reis, Joana
collection PubMed
description Oxidative stress plays a central role in physiological and pathological bone conditions. Its role in signalment and control of bone cell population differentiation, activity, and fate is increasingly recognized. The possibilities of its use and manipulation with therapeutic goals are virtually unending. However, how redox balance interplays with the response to mechanical stimuli is yet to be fully understood. The present work summarizes current knowledge on these aspects, in an integrative and broad introductory perspective.
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spelling pubmed-86506202021-12-08 In Sickness and in Health: The Oxygen Reactive Species and the Bone Reis, Joana Ramos, António Front Bioeng Biotechnol Bioengineering and Biotechnology Oxidative stress plays a central role in physiological and pathological bone conditions. Its role in signalment and control of bone cell population differentiation, activity, and fate is increasingly recognized. The possibilities of its use and manipulation with therapeutic goals are virtually unending. However, how redox balance interplays with the response to mechanical stimuli is yet to be fully understood. The present work summarizes current knowledge on these aspects, in an integrative and broad introductory perspective. Frontiers Media S.A. 2021-11-23 /pmc/articles/PMC8650620/ /pubmed/34888300 http://dx.doi.org/10.3389/fbioe.2021.745911 Text en Copyright © 2021 Reis and Ramos. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Bioengineering and Biotechnology
Reis, Joana
Ramos, António
In Sickness and in Health: The Oxygen Reactive Species and the Bone
title In Sickness and in Health: The Oxygen Reactive Species and the Bone
title_full In Sickness and in Health: The Oxygen Reactive Species and the Bone
title_fullStr In Sickness and in Health: The Oxygen Reactive Species and the Bone
title_full_unstemmed In Sickness and in Health: The Oxygen Reactive Species and the Bone
title_short In Sickness and in Health: The Oxygen Reactive Species and the Bone
title_sort in sickness and in health: the oxygen reactive species and the bone
topic Bioengineering and Biotechnology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8650620/
https://www.ncbi.nlm.nih.gov/pubmed/34888300
http://dx.doi.org/10.3389/fbioe.2021.745911
work_keys_str_mv AT reisjoana insicknessandinhealththeoxygenreactivespeciesandthebone
AT ramosantonio insicknessandinhealththeoxygenreactivespeciesandthebone

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