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The histological effect of tranexamic acid on tendon-to-bone healing histologically in rats

OBJECTIVES: In this study, we aimed to investigate the effect of tranexamic acid (TXA) on osteotendinous junction healing in a rat model, both biomechanically and histologically. MATERIALS AND METHODS: Sixty-four male Wistar-Albino rats weighing 450 to 600 g were used in this study. The rats were di...

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Autores principales: Bozkurt, Orçin, Bağır, Melih, Mirioğlu, Akif, Tekin, Mustafa, Biçer, Ömer Sunkar, Özkan, Cenk, Erdoğan, Kıvılcım
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Bayçınar Medical Publishing 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8650670/
https://www.ncbi.nlm.nih.gov/pubmed/34842101
http://dx.doi.org/10.52312/jdrs.2021.42
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author Bozkurt, Orçin
Bağır, Melih
Mirioğlu, Akif
Tekin, Mustafa
Biçer, Ömer Sunkar
Özkan, Cenk
Erdoğan, Kıvılcım
author_facet Bozkurt, Orçin
Bağır, Melih
Mirioğlu, Akif
Tekin, Mustafa
Biçer, Ömer Sunkar
Özkan, Cenk
Erdoğan, Kıvılcım
author_sort Bozkurt, Orçin
collection PubMed
description OBJECTIVES: In this study, we aimed to investigate the effect of tranexamic acid (TXA) on osteotendinous junction healing in a rat model, both biomechanically and histologically. MATERIALS AND METHODS: Sixty-four male Wistar-Albino rats weighing 450 to 600 g were used in this study. The rats were divided into two groups as the experimental (n=16) and control (n=16) groups. Achillotomy and subsequent repair site was exposed to 1 mL of TXA in the experimental group, while 1 mL of saline was given to the control group. For biomechanical and histopathological investigation, each group was further divided into two subgroups. At the end of four weeks, all rats were sacrificed. Biomechanical tests were performed using the M500-50CT device. The Bonar, Movin, and Nourissat bone-tendon junction scoring systems were used for histopathological evaluation. RESULTS: There was no statistically significant difference in the elongation at a maximum point, maximum loading, and maximum stress variables in the biomechanical study (p=0.558 p=0.775, and p=0.558, respectively). In the histopathological evaluation, the collagen content and layout were close to the native tissue in the experimental group (p=0.047 and p=0.008, respectively). Vascularity, hyalinization, and glycosaminoglycan content were significantly lower in the experimental group (p=0.004, p=0.014, and p=0.026, respectively). The total Bonar and Movin scores were more favorable in the experimental group (p<0.001). CONCLUSION: This experimental study showed that local administration of TXA accelerated bone-tendon junction healing in rats.
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spelling pubmed-86506702021-12-13 The histological effect of tranexamic acid on tendon-to-bone healing histologically in rats Bozkurt, Orçin Bağır, Melih Mirioğlu, Akif Tekin, Mustafa Biçer, Ömer Sunkar Özkan, Cenk Erdoğan, Kıvılcım Jt Dis Relat Surg Original Article OBJECTIVES: In this study, we aimed to investigate the effect of tranexamic acid (TXA) on osteotendinous junction healing in a rat model, both biomechanically and histologically. MATERIALS AND METHODS: Sixty-four male Wistar-Albino rats weighing 450 to 600 g were used in this study. The rats were divided into two groups as the experimental (n=16) and control (n=16) groups. Achillotomy and subsequent repair site was exposed to 1 mL of TXA in the experimental group, while 1 mL of saline was given to the control group. For biomechanical and histopathological investigation, each group was further divided into two subgroups. At the end of four weeks, all rats were sacrificed. Biomechanical tests were performed using the M500-50CT device. The Bonar, Movin, and Nourissat bone-tendon junction scoring systems were used for histopathological evaluation. RESULTS: There was no statistically significant difference in the elongation at a maximum point, maximum loading, and maximum stress variables in the biomechanical study (p=0.558 p=0.775, and p=0.558, respectively). In the histopathological evaluation, the collagen content and layout were close to the native tissue in the experimental group (p=0.047 and p=0.008, respectively). Vascularity, hyalinization, and glycosaminoglycan content were significantly lower in the experimental group (p=0.004, p=0.014, and p=0.026, respectively). The total Bonar and Movin scores were more favorable in the experimental group (p<0.001). CONCLUSION: This experimental study showed that local administration of TXA accelerated bone-tendon junction healing in rats. Bayçınar Medical Publishing 2021-11-19 /pmc/articles/PMC8650670/ /pubmed/34842101 http://dx.doi.org/10.52312/jdrs.2021.42 Text en Copyright © 2021, Turkish Joint Diseases Foundation https://creativecommons.org/licenses/by-nc/4.0/This is an open access article under the terms of the Creative Commons Attribution-NonCommercial License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes.
spellingShingle Original Article
Bozkurt, Orçin
Bağır, Melih
Mirioğlu, Akif
Tekin, Mustafa
Biçer, Ömer Sunkar
Özkan, Cenk
Erdoğan, Kıvılcım
The histological effect of tranexamic acid on tendon-to-bone healing histologically in rats
title The histological effect of tranexamic acid on tendon-to-bone healing histologically in rats
title_full The histological effect of tranexamic acid on tendon-to-bone healing histologically in rats
title_fullStr The histological effect of tranexamic acid on tendon-to-bone healing histologically in rats
title_full_unstemmed The histological effect of tranexamic acid on tendon-to-bone healing histologically in rats
title_short The histological effect of tranexamic acid on tendon-to-bone healing histologically in rats
title_sort histological effect of tranexamic acid on tendon-to-bone healing histologically in rats
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8650670/
https://www.ncbi.nlm.nih.gov/pubmed/34842101
http://dx.doi.org/10.52312/jdrs.2021.42
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