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Association of Cigarette Smoking With Male Cognitive Impairment and Metal Ions in Cerebrospinal Fluid
Objective: Cigarette smoking might accelerate cognitive impairment; however, this has never been investigated using human cerebrospinal fluid (CSF). We conducted this study to investigate the association between cigarette smoking and cognitive impairment through metal ions in CSF. Methods: We obtain...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8650691/ https://www.ncbi.nlm.nih.gov/pubmed/34887785 http://dx.doi.org/10.3389/fpsyt.2021.738358 |
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author | Li, Hui Mu, Qingshuang Kang, Yimin Yang, Xiaoyu Shan, Ligang Wang, Meiling Li, Cunbao Liu, Yanlong Wang, Fan |
author_facet | Li, Hui Mu, Qingshuang Kang, Yimin Yang, Xiaoyu Shan, Ligang Wang, Meiling Li, Cunbao Liu, Yanlong Wang, Fan |
author_sort | Li, Hui |
collection | PubMed |
description | Objective: Cigarette smoking might accelerate cognitive impairment; however, this has never been investigated using human cerebrospinal fluid (CSF). We conducted this study to investigate the association between cigarette smoking and cognitive impairment through metal ions in CSF. Methods: We obtained 5-ml CSF samples from routine lumbar puncture procedures in patients undergoing anterior cruciate ligament reconstruction before surgery in China. A total of 180 Chinese males were recruited (80 active smokers and 100 non-smokers). We measured specific cigarette-related neurotoxic metal ions in CSF, including iron, copper, zinc, lead, aluminum, and manganese. Sociodemographic data and history of smoking were obtained. The Montreal Cognitive Assessment (MoCA) was applied. Results: Active smokers had fewer years of education (11.83 ± 3.13 vs. 13.17 ± 2.60, p = 0.01), and higher age (33.70 ± 10.20 vs. 29.76 ± 9.58, p = 0.01) and body mass index (25.84 ± 3.52 vs. 24.98 ± 4.06, p =0.03) than non-smokers. Compared to non-smokers, active smokers had significantly higher CSF levels of iron, zinc, lead, and aluminum and lower MoCA scores (all p < 0.05). Average daily numbers of cigarettes smoked negatively correlated with the MoCA scores (r = −0.244, p = 0.048). In young smokers, CSF manganese levels negatively correlated with MoCA scores (r = −0.373, p = 0.009). Conclusions and Relevance: Cigarette smoking might be associated with male cognitive impairment, as shown by lower MoCA scores and higher levels of CSF iron, zinc, lead, and aluminum in active smokers. This might be early evidence of cigarette smoking accelerating male cognitive impairment. |
format | Online Article Text |
id | pubmed-8650691 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-86506912021-12-08 Association of Cigarette Smoking With Male Cognitive Impairment and Metal Ions in Cerebrospinal Fluid Li, Hui Mu, Qingshuang Kang, Yimin Yang, Xiaoyu Shan, Ligang Wang, Meiling Li, Cunbao Liu, Yanlong Wang, Fan Front Psychiatry Psychiatry Objective: Cigarette smoking might accelerate cognitive impairment; however, this has never been investigated using human cerebrospinal fluid (CSF). We conducted this study to investigate the association between cigarette smoking and cognitive impairment through metal ions in CSF. Methods: We obtained 5-ml CSF samples from routine lumbar puncture procedures in patients undergoing anterior cruciate ligament reconstruction before surgery in China. A total of 180 Chinese males were recruited (80 active smokers and 100 non-smokers). We measured specific cigarette-related neurotoxic metal ions in CSF, including iron, copper, zinc, lead, aluminum, and manganese. Sociodemographic data and history of smoking were obtained. The Montreal Cognitive Assessment (MoCA) was applied. Results: Active smokers had fewer years of education (11.83 ± 3.13 vs. 13.17 ± 2.60, p = 0.01), and higher age (33.70 ± 10.20 vs. 29.76 ± 9.58, p = 0.01) and body mass index (25.84 ± 3.52 vs. 24.98 ± 4.06, p =0.03) than non-smokers. Compared to non-smokers, active smokers had significantly higher CSF levels of iron, zinc, lead, and aluminum and lower MoCA scores (all p < 0.05). Average daily numbers of cigarettes smoked negatively correlated with the MoCA scores (r = −0.244, p = 0.048). In young smokers, CSF manganese levels negatively correlated with MoCA scores (r = −0.373, p = 0.009). Conclusions and Relevance: Cigarette smoking might be associated with male cognitive impairment, as shown by lower MoCA scores and higher levels of CSF iron, zinc, lead, and aluminum in active smokers. This might be early evidence of cigarette smoking accelerating male cognitive impairment. Frontiers Media S.A. 2021-11-19 /pmc/articles/PMC8650691/ /pubmed/34887785 http://dx.doi.org/10.3389/fpsyt.2021.738358 Text en Copyright © 2021 Li, Mu, Kang, Yang, Shan, Wang, Li, Liu and Wang. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Psychiatry Li, Hui Mu, Qingshuang Kang, Yimin Yang, Xiaoyu Shan, Ligang Wang, Meiling Li, Cunbao Liu, Yanlong Wang, Fan Association of Cigarette Smoking With Male Cognitive Impairment and Metal Ions in Cerebrospinal Fluid |
title | Association of Cigarette Smoking With Male Cognitive Impairment and Metal Ions in Cerebrospinal Fluid |
title_full | Association of Cigarette Smoking With Male Cognitive Impairment and Metal Ions in Cerebrospinal Fluid |
title_fullStr | Association of Cigarette Smoking With Male Cognitive Impairment and Metal Ions in Cerebrospinal Fluid |
title_full_unstemmed | Association of Cigarette Smoking With Male Cognitive Impairment and Metal Ions in Cerebrospinal Fluid |
title_short | Association of Cigarette Smoking With Male Cognitive Impairment and Metal Ions in Cerebrospinal Fluid |
title_sort | association of cigarette smoking with male cognitive impairment and metal ions in cerebrospinal fluid |
topic | Psychiatry |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8650691/ https://www.ncbi.nlm.nih.gov/pubmed/34887785 http://dx.doi.org/10.3389/fpsyt.2021.738358 |
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