Mycolactone enhances the Ca(2+) leak from endoplasmic reticulum by trapping Sec61 translocons in a Ca(2+) permeable state

The Mycobacterium ulcerans exotoxin, mycolactone, is an inhibitor of co-translational translocation via the Sec61 complex. Mycolactone has previously been shown to bind to, and alter the structure of the major translocon subunit Sec61α, and change its interaction with ribosome nascent chain complexe...

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Detalles Bibliográficos
Autores principales: Bhadra, Pratiti, Dos Santos, Scott, Gamayun, Igor, Pick, Tillman, Neumann, Clarissa, Ogbechi, Joy, Hall, Belinda S., Zimmermann, Richard, Helms, Volkhard, Simmonds, Rachel E., Cavalié, Adolfo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Portland Press Ltd. 2021
Materias:
Pharmacology & Toxicology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8650850/
https://www.ncbi.nlm.nih.gov/pubmed/34726690
http://dx.doi.org/10.1042/BCJ20210345

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8650850/
https://www.ncbi.nlm.nih.gov/pubmed/34726690
http://dx.doi.org/10.1042/BCJ20210345

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