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1,25-Dihydroxyvitamin D Inhibits Osteoarthritis by Modulating Interaction Between Vitamin D Receptor and NLRP3 in Macrophages

BACKGROUND: Osteoarthritis (OA) is the most prevalent chronic joint disease globally. Loss of extracellular matrix (ECM) by chondrocytes is a classic feature of OA. Inflammatory cytokines, such as interleukin-1β (IL-1β) and interleukin-18 (IL-18), secreted mainly by macrophages, promote expression o...

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Detalles Bibliográficos
Autores principales:	Duan, Ao, Ma, Zemeng, Liu, Wanshun, Shen, Kai, Zhou, Hao, Wang, Shunbing, Kong, Renyi, Shao, Yuqi, Chen, Yunzi, Guo, Wei, Liu, Feng
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Dove 2021
Materias:	Original Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8651053/ https://www.ncbi.nlm.nih.gov/pubmed/34887675 http://dx.doi.org/10.2147/JIR.S339670

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