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The Extracellular Milieu of Toxoplasma's Lytic Cycle Drives Lab Adaptation, Primarily by Transcriptional Reprogramming

Evolve and resequencing (E&R) was applied to lab adaptation of Toxoplasma gondii for over 1,500 generations with the goal of mapping host-independent in vitro virulence traits. Phenotypic assessments of steps across the lytic cycle revealed that only traits needed in the extracellular milieu evo...

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Detalles Bibliográficos
Autores principales:	Primo, Vincent A., Rezvani, Yasaman, Farrell, Andrew, Murphy, Connor Q., Lou, Jingjing, Vajdi, Amir, Marth, Gabor T., Zarringhalam, Kourosh, Gubbels, Marc-Jan
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society for Microbiology 2021
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8651083/ https://www.ncbi.nlm.nih.gov/pubmed/34874774 http://dx.doi.org/10.1128/mSystems.01196-21

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