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Donafenib-Loaded Callispheres Beads Embolization in a VX2 Liver Tumor: Investigating Efficacy, Safety, and Improvement of Tumor Angiogenesis After Embolization
OBJECTIVE: To investigate the efficiency and safety of callispheres beads loaded with donafenib (DCBs) for embolization in a VX2 liver tumor, as well as the improvement of tumor angiogenesis following embolization. METHODS: Forty New Zealand white rabbit VX2 liver tumors were treated with four diffe...
Autores principales: | , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Dove
2021
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8651093/ https://www.ncbi.nlm.nih.gov/pubmed/34888263 http://dx.doi.org/10.2147/JHC.S337097 |
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author | Li, Tongqiang Shi, Qin Liu, Jiacheng Wang, Yingliang Zhou, Chen Wang, Chaoyang Ju, Shuguang Huang, Songjiang Yang, Chongtu Chen, Yang Bai, Yaowei Xiong, Bin |
author_facet | Li, Tongqiang Shi, Qin Liu, Jiacheng Wang, Yingliang Zhou, Chen Wang, Chaoyang Ju, Shuguang Huang, Songjiang Yang, Chongtu Chen, Yang Bai, Yaowei Xiong, Bin |
author_sort | Li, Tongqiang |
collection | PubMed |
description | OBJECTIVE: To investigate the efficiency and safety of callispheres beads loaded with donafenib (DCBs) for embolization in a VX2 liver tumor, as well as the improvement of tumor angiogenesis following embolization. METHODS: Forty New Zealand white rabbit VX2 liver tumors were treated with four different drugs via the hepatic artery: NS (normal saline), CB (blank callispheres beads), ACB (adriamycin-loaded callispheres beads) and DCB (DCBs). Hematoxylin-eosin staining was performed to assess tumor necrosis, while MRI was employed to detect the changes in tumor size. The safety was evaluated by the liver and kidney function parameters, and the immunofluorescence and immunohistochemical staining were performed to reflect the tumor hypoxia and tumor angiogenesis following embolization. RESULTS: The DCB group had the smallest tumor growth rate, but the tumor necrosis rate was the highest of the four groups. Compared to the CB and ACB groups, the DCB group did not aggravate the liver damage and had no influence on kidney function. The staining results showed that, although the tumor hypoxia deteriorated after DCBs embolization, the expression of VEGF (vascular endothelial growth factor) reduced, thus inhibiting tumor angiogenesis. CONCLUSION: DCB administration via hepatic artery is an effective and safe treatment for a preclinical liver cancer model, with the unique benefit of suppressing tumor angiogenesis following embolization. |
format | Online Article Text |
id | pubmed-8651093 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Dove |
record_format | MEDLINE/PubMed |
spelling | pubmed-86510932021-12-08 Donafenib-Loaded Callispheres Beads Embolization in a VX2 Liver Tumor: Investigating Efficacy, Safety, and Improvement of Tumor Angiogenesis After Embolization Li, Tongqiang Shi, Qin Liu, Jiacheng Wang, Yingliang Zhou, Chen Wang, Chaoyang Ju, Shuguang Huang, Songjiang Yang, Chongtu Chen, Yang Bai, Yaowei Xiong, Bin J Hepatocell Carcinoma Original Research OBJECTIVE: To investigate the efficiency and safety of callispheres beads loaded with donafenib (DCBs) for embolization in a VX2 liver tumor, as well as the improvement of tumor angiogenesis following embolization. METHODS: Forty New Zealand white rabbit VX2 liver tumors were treated with four different drugs via the hepatic artery: NS (normal saline), CB (blank callispheres beads), ACB (adriamycin-loaded callispheres beads) and DCB (DCBs). Hematoxylin-eosin staining was performed to assess tumor necrosis, while MRI was employed to detect the changes in tumor size. The safety was evaluated by the liver and kidney function parameters, and the immunofluorescence and immunohistochemical staining were performed to reflect the tumor hypoxia and tumor angiogenesis following embolization. RESULTS: The DCB group had the smallest tumor growth rate, but the tumor necrosis rate was the highest of the four groups. Compared to the CB and ACB groups, the DCB group did not aggravate the liver damage and had no influence on kidney function. The staining results showed that, although the tumor hypoxia deteriorated after DCBs embolization, the expression of VEGF (vascular endothelial growth factor) reduced, thus inhibiting tumor angiogenesis. CONCLUSION: DCB administration via hepatic artery is an effective and safe treatment for a preclinical liver cancer model, with the unique benefit of suppressing tumor angiogenesis following embolization. Dove 2021-12-03 /pmc/articles/PMC8651093/ /pubmed/34888263 http://dx.doi.org/10.2147/JHC.S337097 Text en © 2021 Li et al. https://creativecommons.org/licenses/by-nc/3.0/This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License (http://creativecommons.org/licenses/by-nc/3.0/ (https://creativecommons.org/licenses/by-nc/3.0/) ). By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms (https://www.dovepress.com/terms.php). |
spellingShingle | Original Research Li, Tongqiang Shi, Qin Liu, Jiacheng Wang, Yingliang Zhou, Chen Wang, Chaoyang Ju, Shuguang Huang, Songjiang Yang, Chongtu Chen, Yang Bai, Yaowei Xiong, Bin Donafenib-Loaded Callispheres Beads Embolization in a VX2 Liver Tumor: Investigating Efficacy, Safety, and Improvement of Tumor Angiogenesis After Embolization |
title | Donafenib-Loaded Callispheres Beads Embolization in a VX2 Liver Tumor: Investigating Efficacy, Safety, and Improvement of Tumor Angiogenesis After Embolization |
title_full | Donafenib-Loaded Callispheres Beads Embolization in a VX2 Liver Tumor: Investigating Efficacy, Safety, and Improvement of Tumor Angiogenesis After Embolization |
title_fullStr | Donafenib-Loaded Callispheres Beads Embolization in a VX2 Liver Tumor: Investigating Efficacy, Safety, and Improvement of Tumor Angiogenesis After Embolization |
title_full_unstemmed | Donafenib-Loaded Callispheres Beads Embolization in a VX2 Liver Tumor: Investigating Efficacy, Safety, and Improvement of Tumor Angiogenesis After Embolization |
title_short | Donafenib-Loaded Callispheres Beads Embolization in a VX2 Liver Tumor: Investigating Efficacy, Safety, and Improvement of Tumor Angiogenesis After Embolization |
title_sort | donafenib-loaded callispheres beads embolization in a vx2 liver tumor: investigating efficacy, safety, and improvement of tumor angiogenesis after embolization |
topic | Original Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8651093/ https://www.ncbi.nlm.nih.gov/pubmed/34888263 http://dx.doi.org/10.2147/JHC.S337097 |
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