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Sex Differences in Non-AIDS Comorbidities Among People With Human Immunodeficiency Virus

Women are grossly underrepresented in human immunodeficiency virus (HIV) clinical and translational research. This is concerning given that people with HIV (PWH) are living longer, and thus accumulating aging-related non-AIDS comorbidities (NACMs); emerging evidence suggests that women are at higher...

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Detalles Bibliográficos
Autores principales: Pond, Renee A, Collins, Lauren F, Lahiri, Cecile D
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8651163/
https://www.ncbi.nlm.nih.gov/pubmed/34888399
http://dx.doi.org/10.1093/ofid/ofab558
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author Pond, Renee A
Collins, Lauren F
Lahiri, Cecile D
author_facet Pond, Renee A
Collins, Lauren F
Lahiri, Cecile D
author_sort Pond, Renee A
collection PubMed
description Women are grossly underrepresented in human immunodeficiency virus (HIV) clinical and translational research. This is concerning given that people with HIV (PWH) are living longer, and thus accumulating aging-related non-AIDS comorbidities (NACMs); emerging evidence suggests that women are at higher risk of NACM development and progression compared with men. It is widely recognized that women vs men have greater immune activation in response to many viruses, including HIV-1; this likely influences sex-differential NACM development related to differences in HIV-associated chronic inflammation. Furthermore, many sociobehavioral factors that contribute to aging-related NACMs are known to differ by sex. The objectives of this review were to (1) synthesize sex-stratified data on 4 NACMs among PWH: bone disease, cardiovascular disease, metabolic dysfunction, and neurocognitive impairment; (2) evaluate the characteristics of key studies assessing sex differences in NACMs; and (3) introduce potential biological and psychosocial mechanisms contributing to emerging trends in sex-differential NACM risk and outcomes among PWH.
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spelling pubmed-86511632021-12-08 Sex Differences in Non-AIDS Comorbidities Among People With Human Immunodeficiency Virus Pond, Renee A Collins, Lauren F Lahiri, Cecile D Open Forum Infect Dis Review Articles Women are grossly underrepresented in human immunodeficiency virus (HIV) clinical and translational research. This is concerning given that people with HIV (PWH) are living longer, and thus accumulating aging-related non-AIDS comorbidities (NACMs); emerging evidence suggests that women are at higher risk of NACM development and progression compared with men. It is widely recognized that women vs men have greater immune activation in response to many viruses, including HIV-1; this likely influences sex-differential NACM development related to differences in HIV-associated chronic inflammation. Furthermore, many sociobehavioral factors that contribute to aging-related NACMs are known to differ by sex. The objectives of this review were to (1) synthesize sex-stratified data on 4 NACMs among PWH: bone disease, cardiovascular disease, metabolic dysfunction, and neurocognitive impairment; (2) evaluate the characteristics of key studies assessing sex differences in NACMs; and (3) introduce potential biological and psychosocial mechanisms contributing to emerging trends in sex-differential NACM risk and outcomes among PWH. Oxford University Press 2021-11-03 /pmc/articles/PMC8651163/ /pubmed/34888399 http://dx.doi.org/10.1093/ofid/ofab558 Text en © The Author(s) 2021. Published by Oxford University Press on behalf of Infectious Diseases Society of America. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs licence (https://creativecommons.org/licenses/by-nc-nd/4.0/), which permits non-commercial reproduction and distribution of the work, in any medium, provided the original work is not altered or transformed in any way, and that the work is properly cited. For commercial re-use, please contact journals.permissions@oup.com
spellingShingle Review Articles
Pond, Renee A
Collins, Lauren F
Lahiri, Cecile D
Sex Differences in Non-AIDS Comorbidities Among People With Human Immunodeficiency Virus
title Sex Differences in Non-AIDS Comorbidities Among People With Human Immunodeficiency Virus
title_full Sex Differences in Non-AIDS Comorbidities Among People With Human Immunodeficiency Virus
title_fullStr Sex Differences in Non-AIDS Comorbidities Among People With Human Immunodeficiency Virus
title_full_unstemmed Sex Differences in Non-AIDS Comorbidities Among People With Human Immunodeficiency Virus
title_short Sex Differences in Non-AIDS Comorbidities Among People With Human Immunodeficiency Virus
title_sort sex differences in non-aids comorbidities among people with human immunodeficiency virus
topic Review Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8651163/
https://www.ncbi.nlm.nih.gov/pubmed/34888399
http://dx.doi.org/10.1093/ofid/ofab558
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