Lactate is an energy substrate for rodent cortical neurons and enhances their firing activity

Glucose is the mandatory fuel for the brain, yet the relative contribution of glucose and lactate for neuronal energy metabolism is unclear. We found that increased lactate, but not glucose concentration, enhances the spiking activity of neurons of the cerebral cortex. Enhanced spiking was dependent...

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Detalles Bibliográficos
Autores principales: Karagiannis, Anastassios, Gallopin, Thierry, Lacroix, Alexandre, Plaisier, Fabrice, Piquet, Juliette, Geoffroy, Hélène, Hepp, Régine, Naudé, Jérémie, Le Gac, Benjamin, Egger, Richard, Lambolez, Bertrand, Li, Dongdong, Rossier, Jean, Staiger, Jochen F, Imamura, Hiromi, Seino, Susumu, Roeper, Jochen, Cauli, Bruno
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2021
Materias:
Neuroscience
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8651295/
https://www.ncbi.nlm.nih.gov/pubmed/34766906
http://dx.doi.org/10.7554/eLife.71424

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