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Influence of Hypovitaminosis D on the Ocurrence of Fractures

Objective  To measure the levels of vitamin D in patients hospitalized for fractures and to evaluate its relationship with fractures. Methods  A primary, analytical, cross-sectional, non-interventional, observational, controlled study was conducted in humans. The serum measurement of: vitamin D, par...

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Autores principales: Valle, Cleandro Augusto Ribeiro do, Pedri, Luiz Alfredo Furtado, Pires, Guilherme Bigonha, Blanco, Mariella Soares, Paula, Bruna Soares, Araújo, Carlos Delano Mundim
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Thieme Revinter Publicações Ltda. 2021
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8651456/
https://www.ncbi.nlm.nih.gov/pubmed/34900108
http://dx.doi.org/10.1055/s-0041-1729585
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author Valle, Cleandro Augusto Ribeiro do
Pedri, Luiz Alfredo Furtado
Pires, Guilherme Bigonha
Blanco, Mariella Soares
Paula, Bruna Soares
Araújo, Carlos Delano Mundim
author_facet Valle, Cleandro Augusto Ribeiro do
Pedri, Luiz Alfredo Furtado
Pires, Guilherme Bigonha
Blanco, Mariella Soares
Paula, Bruna Soares
Araújo, Carlos Delano Mundim
author_sort Valle, Cleandro Augusto Ribeiro do
collection PubMed
description Objective  To measure the levels of vitamin D in patients hospitalized for fractures and to evaluate its relationship with fractures. Methods  A primary, analytical, cross-sectional, non-interventional, observational, controlled study was conducted in humans. The serum measurement of: vitamin D, parathyroid hormone (PTH), calcium, phosphorus, magnesium and albumin was performed in 49 patients who were consecutively hospitalized for surgery due to fracture(s) (study group), and in 50 patients without fractures, from the various outpatient clinics, and who underwent routine tests (control group). Results  The mean level of 25-hydroxyvitamin D (25[OH]D) in patients with fractures was of 23.78 ± 8.01 ng/mL (61.22% of patients with fractures had hypovitaminosis D). The mean 25(OH)D of the control group was of 37.52 ± 9.21 ng/mL (10% of the patients had hypovitaminosis D). Most cases of hypovitaminosis (96%) did not course with secondary hyperparathyroidism (mean PTH = 41.80 ± 22.75 pg/mL). Conclusion  Hypovitaminosis D was found in a significant percentage (61.22%) of the patients who suffered fractures. Further studies on the subject are needed to better understand the influence of hypovitaminosis D on the occurrence of fractures, as well as the benefits of vitamin D supplementation in these patients.
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spelling pubmed-86514562021-12-10 Influence of Hypovitaminosis D on the Ocurrence of Fractures Valle, Cleandro Augusto Ribeiro do Pedri, Luiz Alfredo Furtado Pires, Guilherme Bigonha Blanco, Mariella Soares Paula, Bruna Soares Araújo, Carlos Delano Mundim Rev Bras Ortop (Sao Paulo) Objective  To measure the levels of vitamin D in patients hospitalized for fractures and to evaluate its relationship with fractures. Methods  A primary, analytical, cross-sectional, non-interventional, observational, controlled study was conducted in humans. The serum measurement of: vitamin D, parathyroid hormone (PTH), calcium, phosphorus, magnesium and albumin was performed in 49 patients who were consecutively hospitalized for surgery due to fracture(s) (study group), and in 50 patients without fractures, from the various outpatient clinics, and who underwent routine tests (control group). Results  The mean level of 25-hydroxyvitamin D (25[OH]D) in patients with fractures was of 23.78 ± 8.01 ng/mL (61.22% of patients with fractures had hypovitaminosis D). The mean 25(OH)D of the control group was of 37.52 ± 9.21 ng/mL (10% of the patients had hypovitaminosis D). Most cases of hypovitaminosis (96%) did not course with secondary hyperparathyroidism (mean PTH = 41.80 ± 22.75 pg/mL). Conclusion  Hypovitaminosis D was found in a significant percentage (61.22%) of the patients who suffered fractures. Further studies on the subject are needed to better understand the influence of hypovitaminosis D on the occurrence of fractures, as well as the benefits of vitamin D supplementation in these patients. Thieme Revinter Publicações Ltda. 2021-11-11 /pmc/articles/PMC8651456/ /pubmed/34900108 http://dx.doi.org/10.1055/s-0041-1729585 Text en Sociedade Brasileira de Ortopedia e Traumatologia. This is an open access article published by Thieme under the terms of the Creative Commons Attribution-NonDerivative-NonCommercial License, permitting copying and reproduction so long as the original work is given appropriate credit. Contents may not be used for commecial purposes, or adapted, remixed, transformed or built upon. ( https://creativecommons.org/licenses/by-nc-nd/4.0/ ) https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivatives License, which permits unrestricted reproduction and distribution, for non-commercial purposes only; and use and reproduction, but not distribution, of adapted material for non-commercial purposes only, provided the original work is properly cited.
spellingShingle Valle, Cleandro Augusto Ribeiro do
Pedri, Luiz Alfredo Furtado
Pires, Guilherme Bigonha
Blanco, Mariella Soares
Paula, Bruna Soares
Araújo, Carlos Delano Mundim
Influence of Hypovitaminosis D on the Ocurrence of Fractures
title Influence of Hypovitaminosis D on the Ocurrence of Fractures
title_full Influence of Hypovitaminosis D on the Ocurrence of Fractures
title_fullStr Influence of Hypovitaminosis D on the Ocurrence of Fractures
title_full_unstemmed Influence of Hypovitaminosis D on the Ocurrence of Fractures
title_short Influence of Hypovitaminosis D on the Ocurrence of Fractures
title_sort influence of hypovitaminosis d on the ocurrence of fractures
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8651456/
https://www.ncbi.nlm.nih.gov/pubmed/34900108
http://dx.doi.org/10.1055/s-0041-1729585
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