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Suppression of Interferon-α Treatment Response by Host Negative Factors in Hepatitis B Virus Infection
Chronic hepatitis B virus (CHB) infection remains a major global public health issue for which there is still lacking effective curative treatment. Interferon-α (IFN-α) and its pegylated form have been approved as an anti-HBV drug with the advantage of antiviral activity and host immunity against HB...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Frontiers Media S.A.
2021
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8651562/ https://www.ncbi.nlm.nih.gov/pubmed/34901094 http://dx.doi.org/10.3389/fmed.2021.784172 |
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author | Wang, Jiayi Du, Lingyao Tang, Hong |
author_facet | Wang, Jiayi Du, Lingyao Tang, Hong |
author_sort | Wang, Jiayi |
collection | PubMed |
description | Chronic hepatitis B virus (CHB) infection remains a major global public health issue for which there is still lacking effective curative treatment. Interferon-α (IFN-α) and its pegylated form have been approved as an anti-HBV drug with the advantage of antiviral activity and host immunity against HBV infection enhancement, however, IFN-α treatment failure in CHB patients is a challenging obstacle with 70% of CHB patients respond poorly to exogenous IFN-α treatment. The IFN-α treatment response is negatively regulated by both viral and host factors, and the role of viral factors has been extensively illustrated, while much less attention has been paid to host negative factors. Here, we summarized evidence of host negative regulators and parameters involved in IFN-α therapy failure, review the mechanisms responsible for these effects, and discuss the possible improvement of IFN-based therapy and the rationale of combining the inhibitors of negative regulators in achieving an HBV cure. |
format | Online Article Text |
id | pubmed-8651562 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-86515622021-12-09 Suppression of Interferon-α Treatment Response by Host Negative Factors in Hepatitis B Virus Infection Wang, Jiayi Du, Lingyao Tang, Hong Front Med (Lausanne) Medicine Chronic hepatitis B virus (CHB) infection remains a major global public health issue for which there is still lacking effective curative treatment. Interferon-α (IFN-α) and its pegylated form have been approved as an anti-HBV drug with the advantage of antiviral activity and host immunity against HBV infection enhancement, however, IFN-α treatment failure in CHB patients is a challenging obstacle with 70% of CHB patients respond poorly to exogenous IFN-α treatment. The IFN-α treatment response is negatively regulated by both viral and host factors, and the role of viral factors has been extensively illustrated, while much less attention has been paid to host negative factors. Here, we summarized evidence of host negative regulators and parameters involved in IFN-α therapy failure, review the mechanisms responsible for these effects, and discuss the possible improvement of IFN-based therapy and the rationale of combining the inhibitors of negative regulators in achieving an HBV cure. Frontiers Media S.A. 2021-11-24 /pmc/articles/PMC8651562/ /pubmed/34901094 http://dx.doi.org/10.3389/fmed.2021.784172 Text en Copyright © 2021 Wang, Du and Tang. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Medicine Wang, Jiayi Du, Lingyao Tang, Hong Suppression of Interferon-α Treatment Response by Host Negative Factors in Hepatitis B Virus Infection |
title | Suppression of Interferon-α Treatment Response by Host Negative Factors in Hepatitis B Virus Infection |
title_full | Suppression of Interferon-α Treatment Response by Host Negative Factors in Hepatitis B Virus Infection |
title_fullStr | Suppression of Interferon-α Treatment Response by Host Negative Factors in Hepatitis B Virus Infection |
title_full_unstemmed | Suppression of Interferon-α Treatment Response by Host Negative Factors in Hepatitis B Virus Infection |
title_short | Suppression of Interferon-α Treatment Response by Host Negative Factors in Hepatitis B Virus Infection |
title_sort | suppression of interferon-α treatment response by host negative factors in hepatitis b virus infection |
topic | Medicine |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8651562/ https://www.ncbi.nlm.nih.gov/pubmed/34901094 http://dx.doi.org/10.3389/fmed.2021.784172 |
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