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Suppression of Interferon-α Treatment Response by Host Negative Factors in Hepatitis B Virus Infection

Chronic hepatitis B virus (CHB) infection remains a major global public health issue for which there is still lacking effective curative treatment. Interferon-α (IFN-α) and its pegylated form have been approved as an anti-HBV drug with the advantage of antiviral activity and host immunity against HB...

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Autores principales: Wang, Jiayi, Du, Lingyao, Tang, Hong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8651562/
https://www.ncbi.nlm.nih.gov/pubmed/34901094
http://dx.doi.org/10.3389/fmed.2021.784172
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author Wang, Jiayi
Du, Lingyao
Tang, Hong
author_facet Wang, Jiayi
Du, Lingyao
Tang, Hong
author_sort Wang, Jiayi
collection PubMed
description Chronic hepatitis B virus (CHB) infection remains a major global public health issue for which there is still lacking effective curative treatment. Interferon-α (IFN-α) and its pegylated form have been approved as an anti-HBV drug with the advantage of antiviral activity and host immunity against HBV infection enhancement, however, IFN-α treatment failure in CHB patients is a challenging obstacle with 70% of CHB patients respond poorly to exogenous IFN-α treatment. The IFN-α treatment response is negatively regulated by both viral and host factors, and the role of viral factors has been extensively illustrated, while much less attention has been paid to host negative factors. Here, we summarized evidence of host negative regulators and parameters involved in IFN-α therapy failure, review the mechanisms responsible for these effects, and discuss the possible improvement of IFN-based therapy and the rationale of combining the inhibitors of negative regulators in achieving an HBV cure.
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spelling pubmed-86515622021-12-09 Suppression of Interferon-α Treatment Response by Host Negative Factors in Hepatitis B Virus Infection Wang, Jiayi Du, Lingyao Tang, Hong Front Med (Lausanne) Medicine Chronic hepatitis B virus (CHB) infection remains a major global public health issue for which there is still lacking effective curative treatment. Interferon-α (IFN-α) and its pegylated form have been approved as an anti-HBV drug with the advantage of antiviral activity and host immunity against HBV infection enhancement, however, IFN-α treatment failure in CHB patients is a challenging obstacle with 70% of CHB patients respond poorly to exogenous IFN-α treatment. The IFN-α treatment response is negatively regulated by both viral and host factors, and the role of viral factors has been extensively illustrated, while much less attention has been paid to host negative factors. Here, we summarized evidence of host negative regulators and parameters involved in IFN-α therapy failure, review the mechanisms responsible for these effects, and discuss the possible improvement of IFN-based therapy and the rationale of combining the inhibitors of negative regulators in achieving an HBV cure. Frontiers Media S.A. 2021-11-24 /pmc/articles/PMC8651562/ /pubmed/34901094 http://dx.doi.org/10.3389/fmed.2021.784172 Text en Copyright © 2021 Wang, Du and Tang. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Medicine
Wang, Jiayi
Du, Lingyao
Tang, Hong
Suppression of Interferon-α Treatment Response by Host Negative Factors in Hepatitis B Virus Infection
title Suppression of Interferon-α Treatment Response by Host Negative Factors in Hepatitis B Virus Infection
title_full Suppression of Interferon-α Treatment Response by Host Negative Factors in Hepatitis B Virus Infection
title_fullStr Suppression of Interferon-α Treatment Response by Host Negative Factors in Hepatitis B Virus Infection
title_full_unstemmed Suppression of Interferon-α Treatment Response by Host Negative Factors in Hepatitis B Virus Infection
title_short Suppression of Interferon-α Treatment Response by Host Negative Factors in Hepatitis B Virus Infection
title_sort suppression of interferon-α treatment response by host negative factors in hepatitis b virus infection
topic Medicine
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8651562/
https://www.ncbi.nlm.nih.gov/pubmed/34901094
http://dx.doi.org/10.3389/fmed.2021.784172
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