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Perspectives, past, present and future: the proline cycle/proline-collagen regulatory axis
In the 35 years since the introduction of the “proline cycle”, its relevance to human tumors has been widely established. These connections are based on a variety of mechanisms discovered by many laboratories and have stimulated the search for small molecule inhibitors to treat cancer or metastases....
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Springer Vienna
2021
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8651602/ https://www.ncbi.nlm.nih.gov/pubmed/34825974 http://dx.doi.org/10.1007/s00726-021-03103-7 |
| Sumario: | In the 35 years since the introduction of the “proline cycle”, its relevance to human tumors has been widely established. These connections are based on a variety of mechanisms discovered by many laboratories and have stimulated the search for small molecule inhibitors to treat cancer or metastases. In addition, the multi-layered connections of the proline cycle and the role of proline and hydroxyproline in collagen provide an important regulatory link between the extracellular matrix and metabolism. |
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