Perspectives, past, present and future: the proline cycle/proline-collagen regulatory axis

In the 35 years since the introduction of the “proline cycle”, its relevance to human tumors has been widely established. These connections are based on a variety of mechanisms discovered by many laboratories and have stimulated the search for small molecule inhibitors to treat cancer or metastases....

Descripción completa

Detalles Bibliográficos
Autor principal: Phang, James M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Vienna 2021
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8651602/
https://www.ncbi.nlm.nih.gov/pubmed/34825974
http://dx.doi.org/10.1007/s00726-021-03103-7
_version_ 1784611433581903872
author Phang, James M.
author_facet Phang, James M.
author_sort Phang, James M.
collection PubMed
description In the 35 years since the introduction of the “proline cycle”, its relevance to human tumors has been widely established. These connections are based on a variety of mechanisms discovered by many laboratories and have stimulated the search for small molecule inhibitors to treat cancer or metastases. In addition, the multi-layered connections of the proline cycle and the role of proline and hydroxyproline in collagen provide an important regulatory link between the extracellular matrix and metabolism.
format Online
Article
Text
id pubmed-8651602
institution National Center for Biotechnology Information
language English
publishDate 2021
publisher Springer Vienna
record_format MEDLINE/PubMed
spelling pubmed-86516022021-12-08 Perspectives, past, present and future: the proline cycle/proline-collagen regulatory axis Phang, James M. Amino Acids Original Article In the 35 years since the introduction of the “proline cycle”, its relevance to human tumors has been widely established. These connections are based on a variety of mechanisms discovered by many laboratories and have stimulated the search for small molecule inhibitors to treat cancer or metastases. In addition, the multi-layered connections of the proline cycle and the role of proline and hydroxyproline in collagen provide an important regulatory link between the extracellular matrix and metabolism. Springer Vienna 2021-11-26 2021 /pmc/articles/PMC8651602/ /pubmed/34825974 http://dx.doi.org/10.1007/s00726-021-03103-7 Text en © The Author(s) 2021 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Original Article
Phang, James M.
Perspectives, past, present and future: the proline cycle/proline-collagen regulatory axis
title Perspectives, past, present and future: the proline cycle/proline-collagen regulatory axis
title_full Perspectives, past, present and future: the proline cycle/proline-collagen regulatory axis
title_fullStr Perspectives, past, present and future: the proline cycle/proline-collagen regulatory axis
title_full_unstemmed Perspectives, past, present and future: the proline cycle/proline-collagen regulatory axis
title_short Perspectives, past, present and future: the proline cycle/proline-collagen regulatory axis
title_sort perspectives, past, present and future: the proline cycle/proline-collagen regulatory axis
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8651602/
https://www.ncbi.nlm.nih.gov/pubmed/34825974
http://dx.doi.org/10.1007/s00726-021-03103-7
work_keys_str_mv AT phangjamesm perspectivespastpresentandfuturetheprolinecycleprolinecollagenregulatoryaxis

Ejemplares similares