Activity-induced instabilities of brain organoids

We present an analytical and numerical investigation of the activity-induced hydrodynamic instabilities in model brain organoids. While several mechanisms have been introduced to explain the experimental observation of surface instabilities in brain organoids, the role of activity has been largely o...

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Detalles Bibliográficos
Autores principales: Thijssen, Kristian, Kusters, Guido L. A., Doostmohammadi, Amin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2021
Materias:
Regular Article - Living Systems
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8651611/
https://www.ncbi.nlm.nih.gov/pubmed/34874504
http://dx.doi.org/10.1140/epje/s10189-021-00149-z
Descripción
Sumario:We present an analytical and numerical investigation of the activity-induced hydrodynamic instabilities in model brain organoids. While several mechanisms have been introduced to explain the experimental observation of surface instabilities in brain organoids, the role of activity has been largely overlooked. Our results show that the active stress generated by the cells can be a, previously overlooked, contributor to the emergence of surface deformations in brain organoids. SUPPLEMENTARY INFORMATION: The online version supplementary material available at 10.1140/epje/s10189-021-00149-z.

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