Activity-induced instabilities of brain organoids

We present an analytical and numerical investigation of the activity-induced hydrodynamic instabilities in model brain organoids. While several mechanisms have been introduced to explain the experimental observation of surface instabilities in brain organoids, the role of activity has been largely o...

Descripción completa

Detalles Bibliográficos
Autores principales: Thijssen, Kristian, Kusters, Guido L. A., Doostmohammadi, Amin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2021
Materias:
Regular Article - Living Systems
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8651611/
https://www.ncbi.nlm.nih.gov/pubmed/34874504
http://dx.doi.org/10.1140/epje/s10189-021-00149-z
_version_ 1784611435516526592
author Thijssen, Kristian
Kusters, Guido L. A.
Doostmohammadi, Amin
author_facet Thijssen, Kristian
Kusters, Guido L. A.
Doostmohammadi, Amin
author_sort Thijssen, Kristian
collection PubMed
description We present an analytical and numerical investigation of the activity-induced hydrodynamic instabilities in model brain organoids. While several mechanisms have been introduced to explain the experimental observation of surface instabilities in brain organoids, the role of activity has been largely overlooked. Our results show that the active stress generated by the cells can be a, previously overlooked, contributor to the emergence of surface deformations in brain organoids. SUPPLEMENTARY INFORMATION: The online version supplementary material available at 10.1140/epje/s10189-021-00149-z.
format Online
Article
Text
id pubmed-8651611
institution National Center for Biotechnology Information
language English
publishDate 2021
publisher Springer Berlin Heidelberg
record_format MEDLINE/PubMed
spelling pubmed-86516112021-12-08 Activity-induced instabilities of brain organoids Thijssen, Kristian Kusters, Guido L. A. Doostmohammadi, Amin Eur Phys J E Soft Matter Regular Article - Living Systems We present an analytical and numerical investigation of the activity-induced hydrodynamic instabilities in model brain organoids. While several mechanisms have been introduced to explain the experimental observation of surface instabilities in brain organoids, the role of activity has been largely overlooked. Our results show that the active stress generated by the cells can be a, previously overlooked, contributor to the emergence of surface deformations in brain organoids. SUPPLEMENTARY INFORMATION: The online version supplementary material available at 10.1140/epje/s10189-021-00149-z. Springer Berlin Heidelberg 2021-12-07 2021 /pmc/articles/PMC8651611/ /pubmed/34874504 http://dx.doi.org/10.1140/epje/s10189-021-00149-z Text en © The Author(s) 2021 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Regular Article - Living Systems
Thijssen, Kristian
Kusters, Guido L. A.
Doostmohammadi, Amin
Activity-induced instabilities of brain organoids
title Activity-induced instabilities of brain organoids
title_full Activity-induced instabilities of brain organoids
title_fullStr Activity-induced instabilities of brain organoids
title_full_unstemmed Activity-induced instabilities of brain organoids
title_short Activity-induced instabilities of brain organoids
title_sort activity-induced instabilities of brain organoids
topic Regular Article - Living Systems
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8651611/
https://www.ncbi.nlm.nih.gov/pubmed/34874504
http://dx.doi.org/10.1140/epje/s10189-021-00149-z
work_keys_str_mv AT thijssenkristian activityinducedinstabilitiesofbrainorganoids
AT kustersguidola activityinducedinstabilitiesofbrainorganoids
AT doostmohammadiamin activityinducedinstabilitiesofbrainorganoids

Ejemplares similares