Cargando…

N-glycosylation profiles of the SARS-CoV-2 spike D614G mutant and its ancestral protein characterized by advanced mass spectrometry

N-glycosylation plays an important role in the structure and function of membrane and secreted proteins. The spike protein on the surface of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the virus that causes COVID-19, is heavily glycosylated and the major target for developing v...

Descripción completa

Detalles Bibliográficos
Autores principales:	Wang, Dongxia, Zhou, Bin, Keppel, Theodore R., Solano, Maria, Baudys, Jakub, Goldstein, Jason, Finn, M. G., Fan, Xiaoyu, Chapman, Asheley P., Bundy, Jonathan L., Woolfitt, Adrian R., Osman, Sarah H., Pirkle, James L., Wentworth, David E., Barr, John R.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8651636/ https://www.ncbi.nlm.nih.gov/pubmed/34876606 http://dx.doi.org/10.1038/s41598-021-02904-w

Ejemplares similares

Comprehensive Analysis of the Glycan Complement of SARS-CoV-2 Spike Proteins Using Signature Ions-Triggered Electron-Transfer/Higher-Energy Collisional Dissociation (EThcD) Mass Spectrometry
por: Wang, Dongxia, et al.
Publicado: (2020)

Analysis of the N-glycosylation profiles of the spike proteins from the Alpha, Beta, Gamma, and Delta variants of SARS-CoV-2
por: Wang, Dongxia, et al.
Publicado: (2023)

Recommended Mass Spectrometry-Based Strategies to Identify Botulinum Neurotoxin-Containing Samples
por: Kalb, Suzanne R., et al.
Publicado: (2015)

SARS-CoV-2 spike D614G variant confers enhanced replication and transmissibility
por: Zhou, Bin, et al.
Publicado: (2020)

Stability of SARS-CoV-2 Spike G614 Variant Surpasses That of the D614 Variant after Cold Storage
por: Huang, Sheng-Yu, et al.
Publicado: (2021)

Sensitive detection of type G botulinum neurotoxin through Endopep-MS peptide substrate optimization
por: Wang, Dongxia, et al.
Publicado: (2019)

Further optimization of peptide substrate enhanced assay performance for BoNT/A detection by MALDI-TOF mass spectrometry
por: Wang, Dongxia, et al.
Publicado: (2017)

Effect of D614G Spike Variant on Immunoglobulin G, M, or A Spike Seroassay Performance
por: Klumpp-Thomas, Carleen, et al.
Publicado: (2020)

The effect of the D614G substitution on the structure of the spike glycoprotein of SARS-CoV-2
por: Benton, Donald J., et al.
Publicado: (2021)

Site-Specific Glycosylation Patterns of the SARS-CoV-2 Spike Protein Derived From Recombinant Protein and Viral WA1 and D614G Strains
por: Tian, Yuan, et al.
Publicado: (2021)

Making sense of spike D614G in SARS-CoV-2 transmission
por: Shi, Aria C., et al.
Publicado: (2021)

SARS-CoV-2 spike-protein D614G mutation increases virion spike density and infectivity
por: Zhang, Lizhou, et al.
Publicado: (2020)

Spike mutation D614G alters SARS-CoV-2 fitness and neutralization susceptibility
por: Plante, Jessica A., et al.
Publicado: (2020)

Author Correction: Spike mutation D614G alters SARS-CoV-2 fitness
por: Plante, Jessica A., et al.
Publicado: (2021)

Functional importance of the D614G mutation in the SARS-CoV-2 spike protein
por: Jackson, Cody B., et al.
Publicado: (2021)

Mutational sensitivity of D614G in spike protein of SARS-CoV-2 in Jordan
por: Al-Zyoud, Walid, et al.
Publicado: (2020)

The D614G Mutation Enhances the Lysosomal Trafficking of SARS-CoV-2 Spike
por: Guo, Chenxu, et al.
Publicado: (2020)

D614G Spike Mutation Increases SARS CoV-2 Susceptibility to Neutralization
por: Weissman, Drew, et al.
Publicado: (2021)

Structural impact on SARS-CoV-2 spike protein by D614G substitution
por: Zhang, Jun, et al.
Publicado: (2021)

Structural effects of spike protein D614G mutation in SARS-CoV-2
por: Dokainish, Hisham M., et al.
Publicado: (2023)

Evaluating the Effects of SARS-CoV-2 Spike Mutation D614G on Transmissibility and Pathogenicity
por: Volz, Erik, et al.
Publicado: (2021)

Experimental and in silico evidence suggests vaccines are unlikely to be affected by D614G mutation in SARS-CoV-2 spike protein
por: McAuley, Alexander J., et al.
Publicado: (2020)

The Spike D614G mutation increases SARS-CoV-2 infection of multiple human cell types
por: Daniloski, Zharko, et al.
Publicado: (2021)

Structural and Functional Analysis of the D614G SARS-CoV-2 Spike Protein Variant
por: Yurkovetskiy, Leonid, et al.
Publicado: (2020)

Spike mutation D614G alters SARS-CoV-2 fitness and neutralization susceptibility
por: Shi, Pei-Yong, et al.
Publicado: (2020)

Structural and Functional Analysis of the D614G SARS-CoV-2 Spike Protein Variant
por: Yurkovetskiy, Leonid, et al.
Publicado: (2020)

Amino acid variation analysis of surface spike glycoprotein at 614 in SARS-CoV-2 strains
por: Canhui Cao, et al.
Publicado: (2020)

The SARS-CoV-2 Spike variant D614G favors an open conformational state
por: Mansbach, Rachael A., et al.
Publicado: (2021)

The SARS-CoV-2 Spike Variant D614G Favors an Open Conformational State
por: Mansbach, Rachael A., et al.
Publicado: (2021)

SARS‐CoV‐2 viral spike G614 mutation exhibits higher case fatality rate
por: Becerra‐Flores, Manuel, et al.
Publicado: (2020)

Evolutionary and structural analyses of SARS-CoV-2 D614G spike protein mutation now documented worldwide
por: Isabel, Sandra, et al.
Publicado: (2020)

Detection of the HA-33 protein in botulinum neurotoxin type G complex by mass spectrometry
por: Kalb, Suzanne R., et al.
Publicado: (2015)

Extraction of BoNT/A, /B, /E, and /F with a Single, High Affinity Monoclonal Antibody for Detection of Botulinum Neurotoxin by Endopep-MS
por: Kalb, Suzanne R., et al.
Publicado: (2010)

Spike protein D614G and RdRp P323L: the SARS-CoV-2 mutations associated with severity of COVID-19
por: Biswas, Subrata K., et al.
Publicado: (2020)

The D614G mutation in the SARS-CoV-2 spike protein reduces S1 shedding and increases infectivity
por: Zhang, Lizhou, et al.
Publicado: (2020)

Detection of SARS-CoV-2 spike protein D614G mutation by qPCR-HRM analysis
por: Gazali, Faris Muhammad, et al.
Publicado: (2021)

Epidemiological Model Suggests D614G Spike Protein Mutation Accelerates Transmission of COVID-19 — Worldwide, 2020
por: Wang, Liang, et al.
Publicado: (2020)

D614G substitution at the hinge region enhances the stability of trimeric SARS-CoV-2 spike protein
por: Yazhini, Arangasamy, et al.
Publicado: (2021)

Deep immunological imprinting due to the ancestral spike in the current bivalent COVID-19 vaccine
por: Wang, Qian, et al.
Publicado: (2023)

Selection Against Glycosylation in Ruminant Pancreatic Ribonucleases by Replacements in the Ancestral Carbohydrate Attachment Site
por: Gautschi, Matthias, et al.
Publicado: (2008)

Cannot write session to /tmp/vufind_sessions/sess_nr80c0fhgljrlqn999r48vu9nc