Viral evasion of the integrated stress response through antagonism of eIF2-P binding to eIF2B

Viral infection triggers activation of the integrated stress response (ISR). In response to viral double-stranded RNA (dsRNA), RNA-activated protein kinase (PKR) phosphorylates the translation initiation factor eIF2, converting it from a translation initiator into a potent translation inhibitor and...

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Detalles Bibliográficos
Autores principales: Schoof, Michael, Wang, Lan, Cogan, J. Zachery, Lawrence, Rosalie E., Boone, Morgane, Wuerth, Jennifer Deborah, Frost, Adam, Walter, Peter
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8651678/
https://www.ncbi.nlm.nih.gov/pubmed/34876554
http://dx.doi.org/10.1038/s41467-021-26164-4

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8651678/
https://www.ncbi.nlm.nih.gov/pubmed/34876554
http://dx.doi.org/10.1038/s41467-021-26164-4

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