Nm23-H1 activator phenylbutenoid dimer exerts cytotoxic effects on metastatic breast cancer cells by inducing mitochondrial dysfunction only under glucose starvation

Mitochondrial oxidative phosphorylation (OXPHOS) has become an attractive target in anti-cancer studies in recent years. In this study, we found that a small molecule phenylbutenoid dimer NMac1 (Nm23-H1 activator 1), (±)-trans-3-(3,4-dimethoxyphenyl)-4-[(E)-3,4-dimethoxystyryl]cyclohex-1-ene, a prev...

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Detalles Bibliográficos
Autores principales: Kim, Bokyung, Lee, Jae-Jin, Shin, Ji Soo, Suh, Ji-Wan, Jung, Sunhee, Hwang, Geum-Sook, Lee, Hee-Yoon, Lee, Kong-Joo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8651694/
https://www.ncbi.nlm.nih.gov/pubmed/34876614
http://dx.doi.org/10.1038/s41598-021-02729-7

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8651694/
https://www.ncbi.nlm.nih.gov/pubmed/34876614
http://dx.doi.org/10.1038/s41598-021-02729-7

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