Butyrate producing microbiota are reduced in chronic kidney diseases

Chronic kidney disease is a major public health concern that affects millions of people globally. Alterations in gut microbiota composition have been observed in patients with chronic kidney disease. Nevertheless, the correlation between the gut microbiota and disease severity has not been investiga...

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Autores principales: Gao, Bei, Jose, Adarsh, Alonzo-Palma, Norma, Malik, Taimur, Shankaranarayanan, Divya, Regunathan-Shenk, Renu, Raj, Dominic S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8651744/
https://www.ncbi.nlm.nih.gov/pubmed/34876615
http://dx.doi.org/10.1038/s41598-021-02865-0
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author Gao, Bei
Jose, Adarsh
Alonzo-Palma, Norma
Malik, Taimur
Shankaranarayanan, Divya
Regunathan-Shenk, Renu
Raj, Dominic S.
author_facet Gao, Bei
Jose, Adarsh
Alonzo-Palma, Norma
Malik, Taimur
Shankaranarayanan, Divya
Regunathan-Shenk, Renu
Raj, Dominic S.
author_sort Gao, Bei
collection PubMed
description Chronic kidney disease is a major public health concern that affects millions of people globally. Alterations in gut microbiota composition have been observed in patients with chronic kidney disease. Nevertheless, the correlation between the gut microbiota and disease severity has not been investigated. In this study, we performed shot-gun metagenomics sequencing and identified several taxonomic and functional signatures associated with disease severity in patients with chronic kidney disease. We noted that 19 microbial genera were significantly associated with the severity of chronic kidney disease. The butyrate-producing bacteria were reduced in patients with advanced stages of chronic kidney diseases. In addition, functional metagenomics showed that two-component systems, metabolic activity and regulation of co-factor were significantly associated with the disease severity. Our study provides valuable information for the development of microbiota-oriented therapeutic strategies for chronic kidney disease.
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spelling pubmed-86517442021-12-08 Butyrate producing microbiota are reduced in chronic kidney diseases Gao, Bei Jose, Adarsh Alonzo-Palma, Norma Malik, Taimur Shankaranarayanan, Divya Regunathan-Shenk, Renu Raj, Dominic S. Sci Rep Article Chronic kidney disease is a major public health concern that affects millions of people globally. Alterations in gut microbiota composition have been observed in patients with chronic kidney disease. Nevertheless, the correlation between the gut microbiota and disease severity has not been investigated. In this study, we performed shot-gun metagenomics sequencing and identified several taxonomic and functional signatures associated with disease severity in patients with chronic kidney disease. We noted that 19 microbial genera were significantly associated with the severity of chronic kidney disease. The butyrate-producing bacteria were reduced in patients with advanced stages of chronic kidney diseases. In addition, functional metagenomics showed that two-component systems, metabolic activity and regulation of co-factor were significantly associated with the disease severity. Our study provides valuable information for the development of microbiota-oriented therapeutic strategies for chronic kidney disease. Nature Publishing Group UK 2021-12-07 /pmc/articles/PMC8651744/ /pubmed/34876615 http://dx.doi.org/10.1038/s41598-021-02865-0 Text en © The Author(s) 2021 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Article
Gao, Bei
Jose, Adarsh
Alonzo-Palma, Norma
Malik, Taimur
Shankaranarayanan, Divya
Regunathan-Shenk, Renu
Raj, Dominic S.
Butyrate producing microbiota are reduced in chronic kidney diseases
title Butyrate producing microbiota are reduced in chronic kidney diseases
title_full Butyrate producing microbiota are reduced in chronic kidney diseases
title_fullStr Butyrate producing microbiota are reduced in chronic kidney diseases
title_full_unstemmed Butyrate producing microbiota are reduced in chronic kidney diseases
title_short Butyrate producing microbiota are reduced in chronic kidney diseases
title_sort butyrate producing microbiota are reduced in chronic kidney diseases
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8651744/
https://www.ncbi.nlm.nih.gov/pubmed/34876615
http://dx.doi.org/10.1038/s41598-021-02865-0
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