Protracted clinical course of an AFF1 fusion positive uterine smooth muscle tumor causing diagnostic confusion over a course of 15 years

• Histologic diagnostic criteria alone for uterine smooth muscle tumors lacks robust prognostication. • Molecular/genetic techniques should be advocated to further investigate unusual case presentations. • Novel identification of a PTP4A2-AFF1 genetic fusion was identified. • The novel PTP4A2-AFF1 g...

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Detalles Bibliográficos
Autores principales: Aubrey, Christa, Mal, Hanan, Köbel, Martin, Lee, Cheng-Han, Turashvili, Gulisa, Yip, Stephen, Lum, Amy, Nelson, Gregg
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2021
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8651790/
https://www.ncbi.nlm.nih.gov/pubmed/34926770
http://dx.doi.org/10.1016/j.gore.2021.100890
Descripción
Sumario:• Histologic diagnostic criteria alone for uterine smooth muscle tumors lacks robust prognostication. • Molecular/genetic techniques should be advocated to further investigate unusual case presentations. • Novel identification of a PTP4A2-AFF1 genetic fusion was identified. • The novel PTP4A2-AFF1 genetic fusion may have further diagnostic prognostic, and therapeutic implications.

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