Protracted clinical course of an AFF1 fusion positive uterine smooth muscle tumor causing diagnostic confusion over a course of 15 years

• Histologic diagnostic criteria alone for uterine smooth muscle tumors lacks robust prognostication. • Molecular/genetic techniques should be advocated to further investigate unusual case presentations. • Novel identification of a PTP4A2-AFF1 genetic fusion was identified. • The novel PTP4A2-AFF1 g...

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Detalles Bibliográficos
Autores principales: Aubrey, Christa, Mal, Hanan, Köbel, Martin, Lee, Cheng-Han, Turashvili, Gulisa, Yip, Stephen, Lum, Amy, Nelson, Gregg
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2021
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8651790/
https://www.ncbi.nlm.nih.gov/pubmed/34926770
http://dx.doi.org/10.1016/j.gore.2021.100890
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author Aubrey, Christa
Mal, Hanan
Köbel, Martin
Lee, Cheng-Han
Turashvili, Gulisa
Yip, Stephen
Lum, Amy
Nelson, Gregg
author_facet Aubrey, Christa
Mal, Hanan
Köbel, Martin
Lee, Cheng-Han
Turashvili, Gulisa
Yip, Stephen
Lum, Amy
Nelson, Gregg
author_sort Aubrey, Christa
collection PubMed
description • Histologic diagnostic criteria alone for uterine smooth muscle tumors lacks robust prognostication. • Molecular/genetic techniques should be advocated to further investigate unusual case presentations. • Novel identification of a PTP4A2-AFF1 genetic fusion was identified. • The novel PTP4A2-AFF1 genetic fusion may have further diagnostic prognostic, and therapeutic implications.
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spelling pubmed-86517902021-12-17 Protracted clinical course of an AFF1 fusion positive uterine smooth muscle tumor causing diagnostic confusion over a course of 15 years Aubrey, Christa Mal, Hanan Köbel, Martin Lee, Cheng-Han Turashvili, Gulisa Yip, Stephen Lum, Amy Nelson, Gregg Gynecol Oncol Rep Case Report • Histologic diagnostic criteria alone for uterine smooth muscle tumors lacks robust prognostication. • Molecular/genetic techniques should be advocated to further investigate unusual case presentations. • Novel identification of a PTP4A2-AFF1 genetic fusion was identified. • The novel PTP4A2-AFF1 genetic fusion may have further diagnostic prognostic, and therapeutic implications. Elsevier 2021-11-17 /pmc/articles/PMC8651790/ /pubmed/34926770 http://dx.doi.org/10.1016/j.gore.2021.100890 Text en © 2021 The Authors https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Case Report
Aubrey, Christa
Mal, Hanan
Köbel, Martin
Lee, Cheng-Han
Turashvili, Gulisa
Yip, Stephen
Lum, Amy
Nelson, Gregg
Protracted clinical course of an AFF1 fusion positive uterine smooth muscle tumor causing diagnostic confusion over a course of 15 years
title Protracted clinical course of an AFF1 fusion positive uterine smooth muscle tumor causing diagnostic confusion over a course of 15 years
title_full Protracted clinical course of an AFF1 fusion positive uterine smooth muscle tumor causing diagnostic confusion over a course of 15 years
title_fullStr Protracted clinical course of an AFF1 fusion positive uterine smooth muscle tumor causing diagnostic confusion over a course of 15 years
title_full_unstemmed Protracted clinical course of an AFF1 fusion positive uterine smooth muscle tumor causing diagnostic confusion over a course of 15 years
title_short Protracted clinical course of an AFF1 fusion positive uterine smooth muscle tumor causing diagnostic confusion over a course of 15 years
title_sort protracted clinical course of an aff1 fusion positive uterine smooth muscle tumor causing diagnostic confusion over a course of 15 years
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8651790/
https://www.ncbi.nlm.nih.gov/pubmed/34926770
http://dx.doi.org/10.1016/j.gore.2021.100890
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