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A transient conformation facilitates ligand binding to the adenine riboswitch

RNAs adopt various conformations to perform different functions in cells. Incapable of acquiring intermediates, the key initiations of ligand recognition in the adenine riboswitch have not been characterized. In this work, stopped-flow fluorescence was used to track structural switches in the full-l...

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Detalles Bibliográficos
Autores principales: Wu, Lin, Chen, Dian, Ding, Jienyu, Liu, Yu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8652005/
https://www.ncbi.nlm.nih.gov/pubmed/34927032
http://dx.doi.org/10.1016/j.isci.2021.103512