Kynurenine induces T cell fat catabolism and has limited suppressive effects in vivo

BACKGROUND: L-kynurenine is a tryptophan-derived immunosuppressive metabolite and precursor to neurotoxic anthranilate and quinolinate. We evaluated the stereoisomer D-kynurenine as an immunosuppressive therapeutic which is hypothesized to produce less neurotoxic metabolites than L-kynurenine. METHO...

Descripción completa

Detalles Bibliográficos
Autores principales: Siska, Peter J., Jiao, Jing, Matos, Carina, Singer, Katrin, Dettmer, Katja, Oefner, Peter J., Cully, Michelle D., Wang, Zhonglin, Oliff, Kristen N., Wilkins, Benjamin J., Christensen, Lanette M., Wang, Liqing, Hancock, Wayne W., Baur, Joseph A., Levine, Matthew H., Ugele, Ines, Mayr, Roman, Renner, Kathrin, Zhou, Liang, Kreutz, Marina, Beier, Ulf H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2021
Materias:
Research paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8652007/
https://www.ncbi.nlm.nih.gov/pubmed/34875457
http://dx.doi.org/10.1016/j.ebiom.2021.103734

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8652007/
https://www.ncbi.nlm.nih.gov/pubmed/34875457
http://dx.doi.org/10.1016/j.ebiom.2021.103734

Ejemplares similares