Cargando…

Kynurenine induces T cell fat catabolism and has limited suppressive effects in vivo

BACKGROUND: L-kynurenine is a tryptophan-derived immunosuppressive metabolite and precursor to neurotoxic anthranilate and quinolinate. We evaluated the stereoisomer D-kynurenine as an immunosuppressive therapeutic which is hypothesized to produce less neurotoxic metabolites than L-kynurenine. METHO...

Descripción completa

Detalles Bibliográficos
Autores principales:	Siska, Peter J., Jiao, Jing, Matos, Carina, Singer, Katrin, Dettmer, Katja, Oefner, Peter J., Cully, Michelle D., Wang, Zhonglin, Oliff, Kristen N., Wilkins, Benjamin J., Christensen, Lanette M., Wang, Liqing, Hancock, Wayne W., Baur, Joseph A., Levine, Matthew H., Ugele, Ines, Mayr, Roman, Renner, Kathrin, Zhou, Liang, Kreutz, Marina, Beier, Ulf H.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier 2021
Materias:	Research paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8652007/ https://www.ncbi.nlm.nih.gov/pubmed/34875457 http://dx.doi.org/10.1016/j.ebiom.2021.103734

Ejemplares similares

D-2-Hydroxyglutarate and L-2-Hydroxyglutarate Inhibit IL-12 Secretion by Human Monocyte-Derived Dendritic Cells
por: Ugele, Ines, et al.
Publicado: (2019)

Topical Diclofenac Reprograms Metabolism and Immune Cell Infiltration in Actinic Keratosis
por: Singer, Katrin, et al.
Publicado: (2019)

Antithymocyte Globulin Induces a Tolerogenic Phenotype in Human Dendritic Cells
por: Roider, Tobias, et al.
Publicado: (2016)

Biological and clinical significance of tryptophan-catabolizing enzymes in cutaneous T-cell lymphomas
por: Maliniemi, Pilvi, et al.
Publicado: (2017)

Kynurenine catabolic enzyme KMO regulates HCC growth
por: Shi, Zhaopeng, et al.
Publicado: (2022)

T cell fat catabolism: A novel target for kynurenine?
por: Puccetti, Paolo, et al.
Publicado: (2021)

MCT4 blockade increases the efficacy of immune checkpoint blockade
por: Babl, Nathalie, et al.
Publicado: (2023)

Degradation of D-2-hydroxyglutarate in the presence of isocitrate dehydrogenase mutations
por: Berger, Raffaela S., et al.
Publicado: (2019)

Combined Modulation of Tumor Metabolism by Metformin and Diclofenac in Glioma
por: Gerthofer, Valeria, et al.
Publicado: (2018)

Combined Metabolic Targeting With Metformin and the NSAIDs Diflunisal and Diclofenac Induces Apoptosis in Acute Myeloid Leukemia Cells
por: Renner, Kathrin, et al.
Publicado: (2018)

Metabolic Hallmarks of Tumor and Immune Cells in the Tumor Microenvironment
por: Renner, Kathrin, et al.
Publicado: (2017)

D-2-hydroxyglutarate interferes with HIF-1α stability skewing T-cell metabolism towards oxidative phosphorylation and impairing Th17 polarization
por: Böttcher, Martin, et al.
Publicado: (2018)

LDHB Overexpression Can Partially Overcome T Cell Inhibition by Lactic Acid
por: Decking, Sonja-Maria, et al.
Publicado: (2022)

New Aspects of an Old Drug – Diclofenac Targets MYC and Glucose Metabolism in Tumor Cells
por: Gottfried, Eva, et al.
Publicado: (2013)

Optimized Protocol for the In Situ Derivatization of Glutathione with N-Ethylmaleimide in Cultured Cells and the Simultaneous Determination of Glutathione/Glutathione Disulfide Ratio by HPLC-UV-QTOF-MS
por: Sun, Xueni, et al.
Publicado: (2020)

Characterization of Redox Environment and Tryptophan Catabolism through Kynurenine Pathway in Military Divers’ and Swimmers’ Serum Samples
por: Sánchez Chapul, Laura, et al.
Publicado: (2022)

Acidic Microenvironments Found in Cutaneous Leishmania Lesions Curtail NO-Dependent Antiparasitic Macrophage Activity
por: Frick, Linus, et al.
Publicado: (2022)

Immunometabolism in cancer at a glance
por: Singer, Katrin, et al.
Publicado: (2018)

Lactonization of the Oncometabolite D-2-Hydroxyglutarate Produces a Novel Endogenous Metabolite
por: Berger, Raffaela S., et al.
Publicado: (2021)

Glutamine synthetase expression rescues human dendritic cell survival in a glutamine-deprived environment
por: Schoeppe, Robert, et al.
Publicado: (2023)

The Kynurenine Pathway and Kynurenine 3-Monooxygenase Inhibitors
por: Hughes, Tamera D., et al.
Publicado: (2022)

Characterization of the Methylthioadenosine Phosphorylase Polymorphism rs7023954 - Incidence and Effects on Enzymatic Function in Malignant Melanoma
por: Limm, Katharina, et al.
Publicado: (2016)

Heat-Inactivation of Human Serum Destroys C1 Inhibitor, Pro-motes Immune Complex Formation, and Improves Human T Cell Function
por: Fante, Matthias A., et al.
Publicado: (2021)

Modulation of Enzyme Activity in the Kynurenine Pathway by Kynurenine Monooxygenase Inhibition
por: Phillips, Robert S., et al.
Publicado: (2019)

(13)C-tryptophan breath test detects increased catabolic turnover of tryptophan along the kynurenine pathway in patients with major depressive disorder
por: Teraishi, Toshiya, et al.
Publicado: (2015)

1,25-dihydroxyvitamin-D3 but not the clinically applied marker 25-hydroxyvitamin-D3 predicts survival after stem cell transplantation
por: Peter, Katrin, et al.
Publicado: (2020)

A Biological Circuit Involving Mef2c, Mef2d, and Hdac9 Controls the Immunosuppressive Functions of CD4+Foxp3+ T-Regulatory Cells
por: Di Giorgio, Eros, et al.
Publicado: (2021)

Correcting for natural isotope abundance and tracer impurity in MS-, MS/MS- and high-resolution-multiple-tracer-data from stable isotope labeling experiments with IsoCorrectoR
por: Heinrich, Paul, et al.
Publicado: (2018)

Isotope Ratio Outlier Analysis (IROA) for HPLC–TOFMS-Based Metabolomics of Human Urine
por: Fadil, Fadi, et al.
Publicado: (2022)

Helios Expression Is a Marker of T Cell Activation and Proliferation
por: Akimova, Tatiana, et al.
Publicado: (2011)

Low-density lipoprotein balances T cell metabolism and enhances response to anti-PD-1 blockade in a HCT116 spheroid model
por: Babl, Nathalie, et al.
Publicado: (2023)

Are Kynurenines Accomplices or Principal Villains in Dementia? Maintenance of Kynurenine Metabolism
por: Tanaka, Masaru, et al.
Publicado: (2020)

Kynurenine promotes neonatal heart regeneration by stimulating cardiomyocyte proliferation and cardiac angiogenesis
por: Zhang, Donghong, et al.
Publicado: (2022)

Nuclear Coregulatory Complexes in Tregs as Targets to Promote Anticancer Immune Responses
por: Christensen, Lanette M., et al.
Publicado: (2022)

Gram-Scale Preparation of Cannflavin A from Hemp (Cannabis sativa L.) and Its Inhibitory Effect on Tryptophan Catabolism Enzyme Kynurenine-3-Monooxygenase
por: Puopolo, Tess, et al.
Publicado: (2022)

Interleukin‐6 promotes skeletal muscle catabolism by activating tryptophan–indoleamine 2,3‐dioxygenase 1–kynurenine pathway during intra‐abdominal sepsis
por: Xie, Tingbin, et al.
Publicado: (2023)

The Kynurenine Pathway in Stem Cell Biology
por: Jones, Simon P., et al.
Publicado: (2013)

Metabolic Heterogeneity of Brain Tumor Cells of Proneural and Mesenchymal Origin
por: Seliger, Corinna, et al.
Publicado: (2022)

The Role of Placental Tryptophan Catabolism
por: Sedlmayr, Peter, et al.
Publicado: (2014)

Microbial hexuronate catabolism in biotechnology
por: Kuivanen, Joosu, et al.
Publicado: (2019)

Cannot write session to /tmp/vufind_sessions/sess_m0m6sju57pi722dpa3ktofbc4k