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Recurrent COVID‐19 infection in a case of rituximab‐induced hypogammaglobulinaemia
Patients with immunodeficiency are at an increased risk of recurrent COVID‐19 infection. They may lack the natural immune response that usually confers long‐lasting immunity. Here, we present our experience managing one such patient, who had a COVID‐19 infection twice, 5 months apart. He had a posit...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley & Sons, Ltd
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8652043/ https://www.ncbi.nlm.nih.gov/pubmed/34934508 http://dx.doi.org/10.1002/rcr2.891 |
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author | Daniel, Jefferson Thangakunam, Balamugesh Isaac, Barney Thomas Jesudason Moorthy, Mahesh Christopher, Devasahayam Jesudas |
author_facet | Daniel, Jefferson Thangakunam, Balamugesh Isaac, Barney Thomas Jesudason Moorthy, Mahesh Christopher, Devasahayam Jesudas |
author_sort | Daniel, Jefferson |
collection | PubMed |
description | Patients with immunodeficiency are at an increased risk of recurrent COVID‐19 infection. They may lack the natural immune response that usually confers long‐lasting immunity. Here, we present our experience managing one such patient, who had a COVID‐19 infection twice, 5 months apart. He had a positive SARS‐CoV‐2 real‐time reverse transcription polymerase chain reaction (RT‐PCR) and computed tomography (CT) thorax with classical findings of COVID‐19 on both occasions. He had multiple negative RT‐PCR tests and two CT scans without COVID‐19 features between these two infections. While the antibody response to the first infection was not detectable, the response to the second infection was robust. Live attenuated vaccines are contraindicated in patients with immunodeficiency, and other vaccines may not elicit an adequate immune response. A high index of suspicion for recurrent COVID‐19 is warranted in this group of patients. |
format | Online Article Text |
id | pubmed-8652043 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | John Wiley & Sons, Ltd |
record_format | MEDLINE/PubMed |
spelling | pubmed-86520432021-12-20 Recurrent COVID‐19 infection in a case of rituximab‐induced hypogammaglobulinaemia Daniel, Jefferson Thangakunam, Balamugesh Isaac, Barney Thomas Jesudason Moorthy, Mahesh Christopher, Devasahayam Jesudas Respirol Case Rep Case Reports Patients with immunodeficiency are at an increased risk of recurrent COVID‐19 infection. They may lack the natural immune response that usually confers long‐lasting immunity. Here, we present our experience managing one such patient, who had a COVID‐19 infection twice, 5 months apart. He had a positive SARS‐CoV‐2 real‐time reverse transcription polymerase chain reaction (RT‐PCR) and computed tomography (CT) thorax with classical findings of COVID‐19 on both occasions. He had multiple negative RT‐PCR tests and two CT scans without COVID‐19 features between these two infections. While the antibody response to the first infection was not detectable, the response to the second infection was robust. Live attenuated vaccines are contraindicated in patients with immunodeficiency, and other vaccines may not elicit an adequate immune response. A high index of suspicion for recurrent COVID‐19 is warranted in this group of patients. John Wiley & Sons, Ltd 2021-12-07 /pmc/articles/PMC8652043/ /pubmed/34934508 http://dx.doi.org/10.1002/rcr2.891 Text en © 2021 The Authors. Respirology Case Reports published by John Wiley & Sons Australia, Ltd on behalf of The Asian Pacific Society of Respirology. https://creativecommons.org/licenses/by/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Case Reports Daniel, Jefferson Thangakunam, Balamugesh Isaac, Barney Thomas Jesudason Moorthy, Mahesh Christopher, Devasahayam Jesudas Recurrent COVID‐19 infection in a case of rituximab‐induced hypogammaglobulinaemia |
title | Recurrent COVID‐19 infection in a case of rituximab‐induced hypogammaglobulinaemia |
title_full | Recurrent COVID‐19 infection in a case of rituximab‐induced hypogammaglobulinaemia |
title_fullStr | Recurrent COVID‐19 infection in a case of rituximab‐induced hypogammaglobulinaemia |
title_full_unstemmed | Recurrent COVID‐19 infection in a case of rituximab‐induced hypogammaglobulinaemia |
title_short | Recurrent COVID‐19 infection in a case of rituximab‐induced hypogammaglobulinaemia |
title_sort | recurrent covid‐19 infection in a case of rituximab‐induced hypogammaglobulinaemia |
topic | Case Reports |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8652043/ https://www.ncbi.nlm.nih.gov/pubmed/34934508 http://dx.doi.org/10.1002/rcr2.891 |
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