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Statins in Non-alcoholic Steatohepatitis
Non-alcoholic fatty liver disease (NAFLD) is the primary cause of chronic liver disease. The range is extensive, including hepatocellular carcinoma, cirrhosis, fibrosis, fatty liver, and non-alcoholic steatohepatitis (NASH). NASH is a condition related to obesity, overweight, metabolic syndrome, dia...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Frontiers Media S.A.
2021
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8652077/ https://www.ncbi.nlm.nih.gov/pubmed/34901236 http://dx.doi.org/10.3389/fcvm.2021.777131 |
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author | Torres-Peña, Jose D. Martín-Piedra, Laura Fuentes-Jiménez, Francisco |
author_facet | Torres-Peña, Jose D. Martín-Piedra, Laura Fuentes-Jiménez, Francisco |
author_sort | Torres-Peña, Jose D. |
collection | PubMed |
description | Non-alcoholic fatty liver disease (NAFLD) is the primary cause of chronic liver disease. The range is extensive, including hepatocellular carcinoma, cirrhosis, fibrosis, fatty liver, and non-alcoholic steatohepatitis (NASH). NASH is a condition related to obesity, overweight, metabolic syndrome, diabetes, and dyslipidemia. It is a dynamic condition that can regress to isolated steatosis or progress to fibrosis and cirrhosis. Statins exert anti-inflammatory, proapoptotic, and antifibrotic effects. It has been proposed that these drugs could have a relevant role in NASH. In this review, we provide an overview of current evidence, from mechanisms of statins involved in the modulation of NASH to human trials about the use of statins to treat or attenuate NASH. |
format | Online Article Text |
id | pubmed-8652077 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-86520772021-12-09 Statins in Non-alcoholic Steatohepatitis Torres-Peña, Jose D. Martín-Piedra, Laura Fuentes-Jiménez, Francisco Front Cardiovasc Med Cardiovascular Medicine Non-alcoholic fatty liver disease (NAFLD) is the primary cause of chronic liver disease. The range is extensive, including hepatocellular carcinoma, cirrhosis, fibrosis, fatty liver, and non-alcoholic steatohepatitis (NASH). NASH is a condition related to obesity, overweight, metabolic syndrome, diabetes, and dyslipidemia. It is a dynamic condition that can regress to isolated steatosis or progress to fibrosis and cirrhosis. Statins exert anti-inflammatory, proapoptotic, and antifibrotic effects. It has been proposed that these drugs could have a relevant role in NASH. In this review, we provide an overview of current evidence, from mechanisms of statins involved in the modulation of NASH to human trials about the use of statins to treat or attenuate NASH. Frontiers Media S.A. 2021-11-24 /pmc/articles/PMC8652077/ /pubmed/34901236 http://dx.doi.org/10.3389/fcvm.2021.777131 Text en Copyright © 2021 Torres-Peña, Martín-Piedra and Fuentes-Jiménez. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Cardiovascular Medicine Torres-Peña, Jose D. Martín-Piedra, Laura Fuentes-Jiménez, Francisco Statins in Non-alcoholic Steatohepatitis |
title | Statins in Non-alcoholic Steatohepatitis |
title_full | Statins in Non-alcoholic Steatohepatitis |
title_fullStr | Statins in Non-alcoholic Steatohepatitis |
title_full_unstemmed | Statins in Non-alcoholic Steatohepatitis |
title_short | Statins in Non-alcoholic Steatohepatitis |
title_sort | statins in non-alcoholic steatohepatitis |
topic | Cardiovascular Medicine |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8652077/ https://www.ncbi.nlm.nih.gov/pubmed/34901236 http://dx.doi.org/10.3389/fcvm.2021.777131 |
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