Cargando…

High Rate of Cytomegalovirus Detection in Cholestatic Preterm Infants

Objectives: To evaluate the prevalence of cytomegalovirus (CMV) infection in preterm infants with cholestasis. Study design: Preterm infants (<37 weeks gestational age) with cholestasis were tested for CMV DNA using Taqman PCR in blood cells from sedimented whole blood, plasma, and urine. Infants...

Descripción completa

Detalles Bibliográficos
Autores principales: Teng, Jonas, Elwin, Anne, Omarsdottir, Soley, Aquilano, Giulia, Vanpee, Mireille, Nemeth, Antal, Rahbar, Afsar, Bohlin, Kajsa, Fischler, Björn, Söderberg-Nauclér, Cecilia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8652112/
https://www.ncbi.nlm.nih.gov/pubmed/34900864
http://dx.doi.org/10.3389/fped.2021.754941
_version_ 1784611522848227328
author Teng, Jonas
Elwin, Anne
Omarsdottir, Soley
Aquilano, Giulia
Vanpee, Mireille
Nemeth, Antal
Rahbar, Afsar
Bohlin, Kajsa
Fischler, Björn
Söderberg-Nauclér, Cecilia
author_facet Teng, Jonas
Elwin, Anne
Omarsdottir, Soley
Aquilano, Giulia
Vanpee, Mireille
Nemeth, Antal
Rahbar, Afsar
Bohlin, Kajsa
Fischler, Björn
Söderberg-Nauclér, Cecilia
author_sort Teng, Jonas
collection PubMed
description Objectives: To evaluate the prevalence of cytomegalovirus (CMV) infection in preterm infants with cholestasis. Study design: Preterm infants (<37 weeks gestational age) with cholestasis were tested for CMV DNA using Taqman PCR in blood cells from sedimented whole blood, plasma, and urine. Infants were regarded as positive for CMV if any sample was tested positive. Their mothers were tested for CMV serostatus simultaneously. A control group of non-cholestatic preterm infants, and their mothers, were tested at a similar age. Results: A total of 69 preterm infants with a median gestational age of 26 weeks and 5 days were included, 45 cholestatic and 24 non-cholestatic. Of the cholestatic infants, 31/45 (69%) were CMV positive vs. 3/24 (13%) of the non-cholestatic infants (p < 0.001). Cholestatic infants were equally preterm as the non-cholestatic ones, but were more severely ill. After adjusting for the risk factors necrotizing enterocolitis, prolonged parenteral nutrition, and gestational age, being CMV positive remained significantly associated with cholestasis in a multivariable logistic regression model. Characteristics of CMV-positive and -negative cholestatic infants showed differences only for necrotizing enterocolitis, occurring in 55% (17/31) of CMV positive vs. 21% (3/14) of CMV negative (p = 0.054), and mortality. Eight cholestatic CMV-positive infants died (26%) vs. none of the CMV-negative infants (p = 0.044). Conclusions: CMV DNA was detected in two out of three cholestatic preterm infants, by far more often than in the non-cholestatic control group. Cholestasis with simultaneous detection of CMV DNA may be associated with increased mortality.
format Online
Article
Text
id pubmed-8652112
institution National Center for Biotechnology Information
language English
publishDate 2021
publisher Frontiers Media S.A.
record_format MEDLINE/PubMed
spelling pubmed-86521122021-12-09 High Rate of Cytomegalovirus Detection in Cholestatic Preterm Infants Teng, Jonas Elwin, Anne Omarsdottir, Soley Aquilano, Giulia Vanpee, Mireille Nemeth, Antal Rahbar, Afsar Bohlin, Kajsa Fischler, Björn Söderberg-Nauclér, Cecilia Front Pediatr Pediatrics Objectives: To evaluate the prevalence of cytomegalovirus (CMV) infection in preterm infants with cholestasis. Study design: Preterm infants (<37 weeks gestational age) with cholestasis were tested for CMV DNA using Taqman PCR in blood cells from sedimented whole blood, plasma, and urine. Infants were regarded as positive for CMV if any sample was tested positive. Their mothers were tested for CMV serostatus simultaneously. A control group of non-cholestatic preterm infants, and their mothers, were tested at a similar age. Results: A total of 69 preterm infants with a median gestational age of 26 weeks and 5 days were included, 45 cholestatic and 24 non-cholestatic. Of the cholestatic infants, 31/45 (69%) were CMV positive vs. 3/24 (13%) of the non-cholestatic infants (p < 0.001). Cholestatic infants were equally preterm as the non-cholestatic ones, but were more severely ill. After adjusting for the risk factors necrotizing enterocolitis, prolonged parenteral nutrition, and gestational age, being CMV positive remained significantly associated with cholestasis in a multivariable logistic regression model. Characteristics of CMV-positive and -negative cholestatic infants showed differences only for necrotizing enterocolitis, occurring in 55% (17/31) of CMV positive vs. 21% (3/14) of CMV negative (p = 0.054), and mortality. Eight cholestatic CMV-positive infants died (26%) vs. none of the CMV-negative infants (p = 0.044). Conclusions: CMV DNA was detected in two out of three cholestatic preterm infants, by far more often than in the non-cholestatic control group. Cholestasis with simultaneous detection of CMV DNA may be associated with increased mortality. Frontiers Media S.A. 2021-11-24 /pmc/articles/PMC8652112/ /pubmed/34900864 http://dx.doi.org/10.3389/fped.2021.754941 Text en Copyright © 2021 Teng, Elwin, Omarsdottir, Aquilano, Vanpee, Nemeth, Rahbar, Bohlin, Fischler and Söderberg-Nauclér. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Pediatrics
Teng, Jonas
Elwin, Anne
Omarsdottir, Soley
Aquilano, Giulia
Vanpee, Mireille
Nemeth, Antal
Rahbar, Afsar
Bohlin, Kajsa
Fischler, Björn
Söderberg-Nauclér, Cecilia
High Rate of Cytomegalovirus Detection in Cholestatic Preterm Infants
title High Rate of Cytomegalovirus Detection in Cholestatic Preterm Infants
title_full High Rate of Cytomegalovirus Detection in Cholestatic Preterm Infants
title_fullStr High Rate of Cytomegalovirus Detection in Cholestatic Preterm Infants
title_full_unstemmed High Rate of Cytomegalovirus Detection in Cholestatic Preterm Infants
title_short High Rate of Cytomegalovirus Detection in Cholestatic Preterm Infants
title_sort high rate of cytomegalovirus detection in cholestatic preterm infants
topic Pediatrics
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8652112/
https://www.ncbi.nlm.nih.gov/pubmed/34900864
http://dx.doi.org/10.3389/fped.2021.754941
work_keys_str_mv AT tengjonas highrateofcytomegalovirusdetectionincholestaticpreterminfants
AT elwinanne highrateofcytomegalovirusdetectionincholestaticpreterminfants
AT omarsdottirsoley highrateofcytomegalovirusdetectionincholestaticpreterminfants
AT aquilanogiulia highrateofcytomegalovirusdetectionincholestaticpreterminfants
AT vanpeemireille highrateofcytomegalovirusdetectionincholestaticpreterminfants
AT nemethantal highrateofcytomegalovirusdetectionincholestaticpreterminfants
AT rahbarafsar highrateofcytomegalovirusdetectionincholestaticpreterminfants
AT bohlinkajsa highrateofcytomegalovirusdetectionincholestaticpreterminfants
AT fischlerbjorn highrateofcytomegalovirusdetectionincholestaticpreterminfants
AT soderbergnauclercecilia highrateofcytomegalovirusdetectionincholestaticpreterminfants