BMPR2 mutations and response to inhaled or parenteral prostanoids: a case series

Whether mutations in the BMPR2 gene may influence the response to PAH-specific therapies has not yet been investigated. In this study, in 13 idiopathic, heritable or anorexigen-associated PAH patients, in whom treatment escalation was performed by adding a prostanoid, a greater haemodynamic improvem...

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Autores principales: Scelsi, Laura, Greco, Alessandra, Acquaro, Mauro, Olivieri, Carla, Sobrero, Matteo, Turco, Annalisa, Cappelletti, Donata, Visconti, Luigi Oltrona, Ghio, Stefano
Formato: Online Artículo Texto
Lenguaje:English
Publicado: SAGE Publications 2021
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8652182/
https://www.ncbi.nlm.nih.gov/pubmed/34900222
http://dx.doi.org/10.1177/20458940211037275
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author Scelsi, Laura
Greco, Alessandra
Acquaro, Mauro
Olivieri, Carla
Sobrero, Matteo
Turco, Annalisa
Cappelletti, Donata
Visconti, Luigi Oltrona
Ghio, Stefano
author_facet Scelsi, Laura
Greco, Alessandra
Acquaro, Mauro
Olivieri, Carla
Sobrero, Matteo
Turco, Annalisa
Cappelletti, Donata
Visconti, Luigi Oltrona
Ghio, Stefano
author_sort Scelsi, Laura
collection PubMed
description Whether mutations in the BMPR2 gene may influence the response to PAH-specific therapies has not yet been investigated. In this study, in 13 idiopathic, heritable or anorexigen-associated PAH patients, in whom treatment escalation was performed by adding a prostanoid, a greater haemodynamic improvement was observed in BMPR2-negative than in BMPR2-positive patients.
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spelling pubmed-86521822021-12-09 BMPR2 mutations and response to inhaled or parenteral prostanoids: a case series Scelsi, Laura Greco, Alessandra Acquaro, Mauro Olivieri, Carla Sobrero, Matteo Turco, Annalisa Cappelletti, Donata Visconti, Luigi Oltrona Ghio, Stefano Pulm Circ Case Report Whether mutations in the BMPR2 gene may influence the response to PAH-specific therapies has not yet been investigated. In this study, in 13 idiopathic, heritable or anorexigen-associated PAH patients, in whom treatment escalation was performed by adding a prostanoid, a greater haemodynamic improvement was observed in BMPR2-negative than in BMPR2-positive patients. SAGE Publications 2021-12-06 /pmc/articles/PMC8652182/ /pubmed/34900222 http://dx.doi.org/10.1177/20458940211037275 Text en © The Author(s) 2021 https://creativecommons.org/licenses/by-nc/4.0/Creative Commons Non Commercial CC BY-NC: This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License (https://creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access pages (https://us.sagepub.com/en-us/nam/open-access-at-sage).
spellingShingle Case Report
Scelsi, Laura
Greco, Alessandra
Acquaro, Mauro
Olivieri, Carla
Sobrero, Matteo
Turco, Annalisa
Cappelletti, Donata
Visconti, Luigi Oltrona
Ghio, Stefano
BMPR2 mutations and response to inhaled or parenteral prostanoids: a case series
title BMPR2 mutations and response to inhaled or parenteral prostanoids: a case series
title_full BMPR2 mutations and response to inhaled or parenteral prostanoids: a case series
title_fullStr BMPR2 mutations and response to inhaled or parenteral prostanoids: a case series
title_full_unstemmed BMPR2 mutations and response to inhaled or parenteral prostanoids: a case series
title_short BMPR2 mutations and response to inhaled or parenteral prostanoids: a case series
title_sort bmpr2 mutations and response to inhaled or parenteral prostanoids: a case series
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8652182/
https://www.ncbi.nlm.nih.gov/pubmed/34900222
http://dx.doi.org/10.1177/20458940211037275
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