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Mitochondrial-Linked De Novo Pyrimidine Biosynthesis Dictates Human T-Cell Proliferation but Not Expression of Effector Molecules

T-cell activation upon antigen stimulation is essential for the continuation of the adaptive immune response. Impairment of mitochondrial oxidative phosphorylation is a well-known disruptor of T-cell activation. Dihydroorotate dehydrogenase (DHODH) is a component of the de novo synthesis of pyrimidi...

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Detalles Bibliográficos
Autores principales:	Peeters, Marlies J. W., Aehnlich, Pia, Pizzella, Adriano, Mølgaard, Kasper, Seremet, Tina, Met, Özcan, Rasmussen, Lene Juel, thor Straten, Per, Desler, Claus
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2021
Materias:	Immunology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8652221/ https://www.ncbi.nlm.nih.gov/pubmed/34899685 http://dx.doi.org/10.3389/fimmu.2021.718863

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