Bias, Precision and Timeliness of Historical (Background) Rate Comparison Methods for Vaccine Safety Monitoring: An Empirical Multi-Database Analysis

Using real-world data and past vaccination data, we conducted a large-scale experiment to quantify bias, precision and timeliness of different study designs to estimate historical background (expected) compared to post-vaccination (observed) rates of safety events for several vaccines. We used negat...

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Detalles Bibliográficos
Autores principales: Li, Xintong, Lai, Lana YH, Ostropolets, Anna, Arshad, Faaizah, Tan, Eng Hooi, Casajust, Paula, Alshammari, Thamir M., Duarte-Salles, Talita, Minty, Evan P., Areia, Carlos, Pratt, Nicole, Ryan, Patrick B., Hripcsak, George, Suchard, Marc A., Schuemie, Martijn J., Prieto-Alhambra, Daniel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Pharmacology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8652333/
https://www.ncbi.nlm.nih.gov/pubmed/34899334
http://dx.doi.org/10.3389/fphar.2021.773875

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8652333/
https://www.ncbi.nlm.nih.gov/pubmed/34899334
http://dx.doi.org/10.3389/fphar.2021.773875

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