In vitro and in vivo effects of AVA4746, a novel competitive antagonist of the ligand binding of VLA-4, in B-cell acute lymphoblastic leukemia

Treatment of resistant or recurrent acute lymphoblastic leukemia (ALL) remains a challenge. It was previously demonstrated that the adhesion molecule integrin α4, referred to hereafter as α4, mediates the cell adhesion-mediated drug resistance (CAM-DR) of B-cell ALL by binding to vascular cell adhes...

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Detalles Bibliográficos
Autores principales: Ruan, Yongsheng, Kim, Hye Na, Ogana, Heather A., Gang, Eun Ji, Li, Shuangyue, Liu, Hsiao-Chuan, Bhojwani, Deepa, Wayne, Alan S., Yang, Mo, Kim, Yong-Mi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: D.A. Spandidos 2022
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Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8652384/
https://www.ncbi.nlm.nih.gov/pubmed/34934426
http://dx.doi.org/10.3892/etm.2021.10969

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