AXL targeting by a specific small molecule or monoclonal antibody inhibits renal cell carcinoma progression in an orthotopic mice model

AXL tyrosine kinase activation enhances cancer cell survival, migration, invasiveness, and promotes drug resistance. AXL overexpression is typically detected in a high percentage of renal cell carcinomas (RCCs) and is strongly associated with poor prognosis. Therefore, AXL inhibition represents an a...

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Detalles Bibliográficos
Autores principales: Chen, Tony J., Mydel, Piotr, Benedyk‐Machaczka, Małgorzata, Kamińska, Marta, Kalucka, Urszula, Blø, Magnus, Furriol, Jessica, Gausdal, Gro, Lorens, James, Osman, Tarig, Marti, Hans‐Peter
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2021
Materias:
Original Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8652404/
https://www.ncbi.nlm.nih.gov/pubmed/34877810
http://dx.doi.org/10.14814/phy2.15140

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8652404/
https://www.ncbi.nlm.nih.gov/pubmed/34877810
http://dx.doi.org/10.14814/phy2.15140

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