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The role of streptavidin and its variants in catalysis by biotinylated secondary amines

Here, we combine the use of host screening, protein crystallography and QM/MM molecular dynamics simulations to investigate how the protein structure affects iminium catalysis by biotinylated secondary amines in a model 1,4 conjugate addition reaction. Monomeric streptavidin (M-Sav) lacks a quaterna...

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Detalles Bibliográficos
Autores principales:	Nödling, Alexander R., Santi, Nicolò, Castillo, Raquel, Lipka-Lloyd, Magdalena, Jin, Yi, Morrill, Louis C., Świderek, Katarzyna, Moliner, Vicent, Luk, Louis Y. P.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	The Royal Society of Chemistry 2021
Materias:	Chemistry
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8652411/ https://www.ncbi.nlm.nih.gov/pubmed/34825690 http://dx.doi.org/10.1039/d1ob01947c

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