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Thermostability-based binding assays reveal complex interplay of cation, substrate and lipid binding in the bacterial DASS transporter, VcINDY

The divalent anion sodium symporter (DASS) family of transporters (SLC13 family in humans) are key regulators of metabolic homeostasis, disruption of which results in protection from diabetes and obesity, and inhibition of liver cancer cell proliferation. Thus, DASS transporter inhibitors are attrac...

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Detalles Bibliográficos
Autores principales:	Sampson, Connor D. D., Fàbregas Bellavista, Cristina, Stewart, Matthew J., Mulligan, Christopher
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Portland Press Ltd. 2021
Materias:	Biophysics
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8652582/ https://www.ncbi.nlm.nih.gov/pubmed/34643224 http://dx.doi.org/10.1042/BCJ20210061

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