Adequate immune response after SARS‐CoV‐2 infection and single dose vaccination despite rapid heart transplantation

Adequate immune response to vaccination remains a challenge in patients after solid organ transplantation. We report a case of a 61‐year‐old male patient who received a left ventricular assist device as a bridge to transplant therapy. Three months before transplantation, he suffered mild SARS‐CoV‐2...

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Autores principales: Erbel‐Khurtsidze, Sophiko, Immohr, Moritz Benjamin, Akhyari, Payam, Tudorache, Igor, Aubin, Hug, Bruno, Raphael Romano, Westenfeld, Ralf, Feldt, Torsten, Lübke, Nadine, Lichtenberg, Artur, Boeken, Udo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2021
Materias:
Case Reports
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8652618/
https://www.ncbi.nlm.nih.gov/pubmed/34608773
http://dx.doi.org/10.1002/ehf2.13635
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author Erbel‐Khurtsidze, Sophiko
Immohr, Moritz Benjamin
Akhyari, Payam
Tudorache, Igor
Aubin, Hug
Bruno, Raphael Romano
Westenfeld, Ralf
Feldt, Torsten
Lübke, Nadine
Lichtenberg, Artur
Boeken, Udo
author_facet Erbel‐Khurtsidze, Sophiko
Immohr, Moritz Benjamin
Akhyari, Payam
Tudorache, Igor
Aubin, Hug
Bruno, Raphael Romano
Westenfeld, Ralf
Feldt, Torsten
Lübke, Nadine
Lichtenberg, Artur
Boeken, Udo
author_sort Erbel‐Khurtsidze, Sophiko
collection PubMed
description Adequate immune response to vaccination remains a challenge in patients after solid organ transplantation. We report a case of a 61‐year‐old male patient who received a left ventricular assist device as a bridge to transplant therapy. Three months before transplantation, he suffered mild SARS‐CoV‐2 infection and was successfully discharged thereafter. Eight days before his successful heart transplantation, he received mRNA BNT 162b2 vaccination. Immediately after transplantation, we detected sufficient rise of nucleocapsid and spike antibodies despite immune suppression therapy. We suspect potential booster effects of the previous SARS‐CoV‐2 infection giving rise to adequate immune response following single vaccination.
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spelling pubmed-86526182021-12-08 Adequate immune response after SARS‐CoV‐2 infection and single dose vaccination despite rapid heart transplantation Erbel‐Khurtsidze, Sophiko Immohr, Moritz Benjamin Akhyari, Payam Tudorache, Igor Aubin, Hug Bruno, Raphael Romano Westenfeld, Ralf Feldt, Torsten Lübke, Nadine Lichtenberg, Artur Boeken, Udo ESC Heart Fail Case Reports Adequate immune response to vaccination remains a challenge in patients after solid organ transplantation. We report a case of a 61‐year‐old male patient who received a left ventricular assist device as a bridge to transplant therapy. Three months before transplantation, he suffered mild SARS‐CoV‐2 infection and was successfully discharged thereafter. Eight days before his successful heart transplantation, he received mRNA BNT 162b2 vaccination. Immediately after transplantation, we detected sufficient rise of nucleocapsid and spike antibodies despite immune suppression therapy. We suspect potential booster effects of the previous SARS‐CoV‐2 infection giving rise to adequate immune response following single vaccination. John Wiley and Sons Inc. 2021-10-04 /pmc/articles/PMC8652618/ /pubmed/34608773 http://dx.doi.org/10.1002/ehf2.13635 Text en © 2021 The Authors. ESC Heart Failure published by John Wiley & Sons Ltd on behalf of European Society of Cardiology. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc-nd/4.0/ (https://creativecommons.org/licenses/by-nc-nd/4.0/) License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made.
spellingShingle Case Reports
Erbel‐Khurtsidze, Sophiko
Immohr, Moritz Benjamin
Akhyari, Payam
Tudorache, Igor
Aubin, Hug
Bruno, Raphael Romano
Westenfeld, Ralf
Feldt, Torsten
Lübke, Nadine
Lichtenberg, Artur
Boeken, Udo
Adequate immune response after SARS‐CoV‐2 infection and single dose vaccination despite rapid heart transplantation
title Adequate immune response after SARS‐CoV‐2 infection and single dose vaccination despite rapid heart transplantation
title_full Adequate immune response after SARS‐CoV‐2 infection and single dose vaccination despite rapid heart transplantation
title_fullStr Adequate immune response after SARS‐CoV‐2 infection and single dose vaccination despite rapid heart transplantation
title_full_unstemmed Adequate immune response after SARS‐CoV‐2 infection and single dose vaccination despite rapid heart transplantation
title_short Adequate immune response after SARS‐CoV‐2 infection and single dose vaccination despite rapid heart transplantation
title_sort adequate immune response after sars‐cov‐2 infection and single dose vaccination despite rapid heart transplantation
topic Case Reports
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8652618/
https://www.ncbi.nlm.nih.gov/pubmed/34608773
http://dx.doi.org/10.1002/ehf2.13635
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