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SARS‐CoV‐2 targeting by RNAi and host complement inhibition: A two‐pronged subterfuge for COVID‐19 treatment
BACKGROUND: The lack of knowledge about the specific preventive measures and limited scientific information on severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) led to an excruciating onset and progression of coronavirus disease 2019 (COVID‐19). Swift development of various successful vac...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley and Sons Inc.
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8652782/ https://www.ncbi.nlm.nih.gov/pubmed/34644457 http://dx.doi.org/10.1002/iid3.549 |
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author | Naqvi, Raza Ali Shukla, Deepak Naqvi, Afsar R. |
author_facet | Naqvi, Raza Ali Shukla, Deepak Naqvi, Afsar R. |
author_sort | Naqvi, Raza Ali |
collection | PubMed |
description | BACKGROUND: The lack of knowledge about the specific preventive measures and limited scientific information on severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) led to an excruciating onset and progression of coronavirus disease 2019 (COVID‐19). Swift development of various successful vaccines around the globe is striving to contain the exponential surges of COVID‐19 cases. However, the ongoing struggle to vaccinate the global population and alarming spread of highly transmissible variants may thwart global initiatives to contain SARS‐CoV‐2 as observed by less robust protective immunity. METHODS: In this perspective, we propose a thought‐provoking, two‐pronged strategy involving RNA interference approach to degrade essential SARS‐CoV‐2 ORFs required for replication and entry in conjunction with a complement inhibitor (compstatin) to stymie the detrimental proinflammatory cytokine storm that exacerbate disease progression and severity. RESULTS: We provide supporting evidence suggesting that concurrent targeting of viral and host components will be a superior strategy to effectively suppress viral spread and clinical manifestations of COVID‐19. CONCLUSION: SARS‐CoV‐2 specific RNAi in conjunction with systemic delivery of compstatin will be an effective two‐pronged strategy to combat local and systemic immune responses in both symptomatic and asymptomatic COVID‐19 patients. |
format | Online Article Text |
id | pubmed-8652782 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | John Wiley and Sons Inc. |
record_format | MEDLINE/PubMed |
spelling | pubmed-86527822021-12-08 SARS‐CoV‐2 targeting by RNAi and host complement inhibition: A two‐pronged subterfuge for COVID‐19 treatment Naqvi, Raza Ali Shukla, Deepak Naqvi, Afsar R. Immun Inflamm Dis Review Articles BACKGROUND: The lack of knowledge about the specific preventive measures and limited scientific information on severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) led to an excruciating onset and progression of coronavirus disease 2019 (COVID‐19). Swift development of various successful vaccines around the globe is striving to contain the exponential surges of COVID‐19 cases. However, the ongoing struggle to vaccinate the global population and alarming spread of highly transmissible variants may thwart global initiatives to contain SARS‐CoV‐2 as observed by less robust protective immunity. METHODS: In this perspective, we propose a thought‐provoking, two‐pronged strategy involving RNA interference approach to degrade essential SARS‐CoV‐2 ORFs required for replication and entry in conjunction with a complement inhibitor (compstatin) to stymie the detrimental proinflammatory cytokine storm that exacerbate disease progression and severity. RESULTS: We provide supporting evidence suggesting that concurrent targeting of viral and host components will be a superior strategy to effectively suppress viral spread and clinical manifestations of COVID‐19. CONCLUSION: SARS‐CoV‐2 specific RNAi in conjunction with systemic delivery of compstatin will be an effective two‐pronged strategy to combat local and systemic immune responses in both symptomatic and asymptomatic COVID‐19 patients. John Wiley and Sons Inc. 2021-10-13 /pmc/articles/PMC8652782/ /pubmed/34644457 http://dx.doi.org/10.1002/iid3.549 Text en © 2021 The Authors. Immunity, Inflammation and Disease published by John Wiley & Sons Ltd. https://creativecommons.org/licenses/by/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Review Articles Naqvi, Raza Ali Shukla, Deepak Naqvi, Afsar R. SARS‐CoV‐2 targeting by RNAi and host complement inhibition: A two‐pronged subterfuge for COVID‐19 treatment |
title | SARS‐CoV‐2 targeting by RNAi and host complement inhibition: A two‐pronged subterfuge for COVID‐19 treatment |
title_full | SARS‐CoV‐2 targeting by RNAi and host complement inhibition: A two‐pronged subterfuge for COVID‐19 treatment |
title_fullStr | SARS‐CoV‐2 targeting by RNAi and host complement inhibition: A two‐pronged subterfuge for COVID‐19 treatment |
title_full_unstemmed | SARS‐CoV‐2 targeting by RNAi and host complement inhibition: A two‐pronged subterfuge for COVID‐19 treatment |
title_short | SARS‐CoV‐2 targeting by RNAi and host complement inhibition: A two‐pronged subterfuge for COVID‐19 treatment |
title_sort | sars‐cov‐2 targeting by rnai and host complement inhibition: a two‐pronged subterfuge for covid‐19 treatment |
topic | Review Articles |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8652782/ https://www.ncbi.nlm.nih.gov/pubmed/34644457 http://dx.doi.org/10.1002/iid3.549 |
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