Angiogenesis, Anti-Tumor, and Anti-Metastatic Activity of Novel α-Substituted Hetero-Aromatic Chalcone Hybrids as Inhibitors of Microtubule Polymerization

A library of new heteroaromatic ring-linked chalcone analogs were designed and synthesized of these, compound 7m with α-CH(3) substitution and bearing a benzofuran ring, displaying the most potent activity, with IC(50) values of 0.07–0.183 µM against three cancer cells. Its low cytotoxicity toward n...

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Detalles Bibliográficos
Autores principales: Sun, Moran, Wang, Yuyang, Yuan, Minghua, Zhao, Qing, Zhang, Yixin, Yao, Yongfang, Duan, Yongtao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8652888/
https://www.ncbi.nlm.nih.gov/pubmed/34900935
http://dx.doi.org/10.3389/fchem.2021.766201

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8652888/
https://www.ncbi.nlm.nih.gov/pubmed/34900935
http://dx.doi.org/10.3389/fchem.2021.766201

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