Cargando…

Angiogenesis, Anti-Tumor, and Anti-Metastatic Activity of Novel α-Substituted Hetero-Aromatic Chalcone Hybrids as Inhibitors of Microtubule Polymerization

A library of new heteroaromatic ring-linked chalcone analogs were designed and synthesized of these, compound 7m with α-CH(3) substitution and bearing a benzofuran ring, displaying the most potent activity, with IC(50) values of 0.07–0.183 µM against three cancer cells. Its low cytotoxicity toward n...

Descripción completa

Detalles Bibliográficos
Autores principales:	Sun, Moran, Wang, Yuyang, Yuan, Minghua, Zhao, Qing, Zhang, Yixin, Yao, Yongfang, Duan, Yongtao
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2021
Materias:	Chemistry
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8652888/ https://www.ncbi.nlm.nih.gov/pubmed/34900935 http://dx.doi.org/10.3389/fchem.2021.766201

Ejemplares similares

Identification of novel non-toxic and anti-angiogenic α-fluorinated chalcones as potent colchicine binding site inhibitors
por: Sun, Moran, et al.
Publicado: (2022)

Angiogenesis and anti-leukaemia activity of novel indole derivatives as potent colchicine binding site inhibitors
por: Yao, Yongfang, et al.
Publicado: (2022)

Antimycobacterial and Anti-Inflammatory Activities of Substituted Chalcones Focusing on an Anti-Tuberculosis Dual Treatment Approach
por: Ventura, Thatiana Lopes Biá, et al.
Publicado: (2015)

Tuning phenoxyl-substituted diketopyrrolopyrroles from quinoidal to biradical ground states through (hetero-)aromatic linkers
por: Rausch, Rodger, et al.
Publicado: (2020)

Investigation of the Biological Properties of (Hetero)Aromatic Thiosemicarbazones
por: Serda, Maciej, et al.
Publicado: (2012)

Evaluation of the Anti-Inflammatory Effect of Chalcone and Chalcone Analogues in a Zebrafish Model
por: Chen, Yau-Hung, et al.
Publicado: (2013)

Intra- versus intermolecular electron transfer in radical nucleophilic aromatic substitution of dihalo(hetero)arenes – a tool for estimating π-conjugation in aromatic systems
por: Janhsen, B., et al.
Publicado: (2017)

Bis- and mono-substituted Chalcones exert anti-feedant and toxic effects on fall armyworm Spodoptera frugiperda
por: Priyanca Devi, Ahanthem, et al.
Publicado: (2021)

Evaluation of Anti-nociceptive and Anti-inflammatory Activities of Novel Chalcone Derivatives
por: Razmi, Ali, et al.
Publicado: (2013)

Conjugated Nanohoops Incorporating Donor, Acceptor, Hetero‐ or Polycyclic Aromatics
por: Hermann, Mathias, et al.
Publicado: (2021)

Design, Synthesis, and Biological Evaluation of Aromatic Amide-Substituted Benzimidazole-Derived Chalcones. The Effect of Upregulating TP53 Protein Expression
por: Wu, Lintao, et al.
Publicado: (2020)

Hetero-Type Benzannulation Leading to Substituted Benzothio-Phenes
por: Kono, Taro, et al.
Publicado: (2021)

Self-anti-angiogenesis nanoparticles enhance anti-metastatic-tumor efficacy of chemotherapeutics
por: Luo, Jiamao, et al.
Publicado: (2021)

Indolyl-chalcone derivatives trigger apoptosis in cisplatin-resistant mesothelioma cells through aberrant tubulin polymerization and deregulation of microtubule-associated proteins
por: Steinlein, Sophia, et al.
Publicado: (2023)

Design of potent fluoro-substituted chalcones as antimicrobial agents
por: Burmaoglu, Serdar, et al.
Publicado: (2017)

Direct sulfonamidation of (hetero)aromatic C–H bonds with sulfonyl azides: a novel and efficient route to N-(hetero)aryl sulfonamides
por: Liu, Zhi, et al.
Publicado: (2020)

Identification and validation of the mode of action of the chalcone anti-mycobacterial compounds
por: Anagani, B., et al.
Publicado: (2020)

Non‐Oxidative Enzymatic (De)Carboxylation of (Hetero)Aromatics and Acrylic Acid Derivatives
por: Payer, Stefan E., et al.
Publicado: (2019)

Progress and recent trends in the direct selenocyanation of (hetero)aromatic C–H bonds
por: Hassanpour, Akbar, et al.
Publicado: (2021)

Challenging cross couplings, in water, aided by in situ iodination of (hetero)aromatic bromides
por: Thomas, Rohan M., et al.
Publicado: (2023)

A molecular analysis of substituted phenylethylamines as potential microtubule targeting agents through in silico methods and in vitro microtubule-polymerization activity
por: De Abreu, Isadora Rocha, et al.
Publicado: (2023)

Chalcone derivatives: synthesis, in vitro and in vivo evaluation of their anti-anxiety, anti-depression and analgesic effects
por: Higgs, Josefina, et al.
Publicado: (2019)

Comprehensive insight into anti-staphylococcal and anti-enterococcal action of brominated and chlorinated pyrazine-based chalcones
por: Konečná, Klára, et al.
Publicado: (2022)

Anti-angiogenesis is anti-actin
por: Sreenivasan, Aparna
Publicado: (2004)

Modulatory Effects of Caffeine and Pentoxifylline on Aromatic Antibiotics: A Role for Hetero-Complex Formation
por: Woziwodzka, Anna, et al.
Publicado: (2021)

The Antioxidant, Anti-Inflammatory, and Neuroprotective Properties of the Synthetic Chalcone Derivative AN07
por: Chen, Yih-Fung, et al.
Publicado: (2020)

Preliminary Insight of Pyrrolylated-Chalcones as New Anti-Methicillin-Resistant Staphylococcus aureus (Anti-MRSA) Agents
por: Gunasekharan, Mohanapriya, et al.
Publicado: (2021)

The Synthesis and Evaluation of Novel Hydroxyl Substituted Chalcone Analogs with in Vitro Anti-Free Radicals Pharmacological Activity and in Vivo Anti-Oxidation Activity in a Free Radical-Injury Alzheimer’s Model
por: Pan, Ying, et al.
Publicado: (2013)

Reaction of Chalcones with Cellular Thiols. The Effect of the 4-Substitution of Chalcones and Protonation State of the Thiols on the Addition Process. Diastereoselective Thiol Addition
por: Kenari, Fatemeh, et al.
Publicado: (2021)

A novel chalcone derivative exerts anti-inflammatory and anti-oxidant effects after acute lung injury
por: Lin, Yuting, et al.
Publicado: (2019)

Sonochemical Synthesis of 2’-Hydroxy-Chalcone Derivatives with Potential Anti-Oomycete Activity
por: López, Génesis, et al.
Publicado: (2020)

Concerted Nucleophilic Aromatic Substitutions
por: Kwan, Eugene E., et al.
Publicado: (2018)

An Electron-Transporting Thiazole-Based Polymer Synthesized Through Direct (Hetero)Arylation Polymerization
por: Chávez, Patricia, et al.
Publicado: (2018)

Antioxidant Activities of Alkyl Substituted Pyrazine Derivatives of Chalcones—In Vitro and In Silico Study
por: Stepanić, Višnja, et al.
Publicado: (2019)

DFT Study of Regio- and Stereoselective 13DC Reaction between Diazopropane and Substituted Chalcone Derivatives: Molecular Docking of Novel Pyrazole Derivatives as Anti-Alzheimer’s Agents
por: Al-Hazmy, Sadeq M., et al.
Publicado: (2023)

Diclofenac: A Nonsteroidal Anti-Inflammatory Drug Inducing Cancer Cell Death by Inhibiting Microtubule Polymerization and Autophagy Flux
por: Choi, Soohee, et al.
Publicado: (2022)

Functionality study of chalcone-hydroxypyridinone hybrids as tyrosinase inhibitors and influence on anti-tyrosinase activity
por: Singh, L. Ravithej, et al.
Publicado: (2020)

In vitro anti-malarial efficacy of chalcones: cytotoxicity profile, mechanism of action and their effect on erythrocytes
por: Sinha, Shweta, et al.
Publicado: (2019)

A New Chalcone Derivative with Promising Antiproliferative and Anti-Invasion Activities in Glioblastoma Cells
por: Mendanha, Daniel, et al.
Publicado: (2021)

Synthesis and Evaluation of Chalcone-Quinoline Based Molecular Hybrids as Potential Anti-Malarial Agents
por: Vinindwa, Bonani, et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_g5bbogsmi44h7192kb7e9h1scj