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sFlt-1/PlGF ratio in hypertensive disorders of pregnancy in patients affected by COVID-19
OBJECTIVES: To analyze soluble Fms-like tyrosine Kinase 1 (sFlt-1) and Placental Growth Factor (PlGF) ratio concentrations in COVID-19 pregnant patients with and without Hypertensive Disorders of Pregnancy (HDP), compared with non COVID-19 pregnant patients with HDP and a control group. STUDY DESIGN...
Autores principales: | , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
International Society for the Study of Hypertension in Pregnancy. Published by Elsevier B.V.
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8653398/ https://www.ncbi.nlm.nih.gov/pubmed/34998223 http://dx.doi.org/10.1016/j.preghy.2021.12.001 |
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author | Soldavini, Chiara Maria Di Martino, Daniela Sabattini, Elisa Ornaghi, Sara Sterpi, Vittoria Erra, Roberta Invernizzi, Francesca Tine', Gabriele Giardini, Valentina Vergani, Patrizia Ossola, Manuela Wally Ferrazzi, Enrico |
author_facet | Soldavini, Chiara Maria Di Martino, Daniela Sabattini, Elisa Ornaghi, Sara Sterpi, Vittoria Erra, Roberta Invernizzi, Francesca Tine', Gabriele Giardini, Valentina Vergani, Patrizia Ossola, Manuela Wally Ferrazzi, Enrico |
author_sort | Soldavini, Chiara Maria |
collection | PubMed |
description | OBJECTIVES: To analyze soluble Fms-like tyrosine Kinase 1 (sFlt-1) and Placental Growth Factor (PlGF) ratio concentrations in COVID-19 pregnant patients with and without Hypertensive Disorders of Pregnancy (HDP), compared with non COVID-19 pregnant patients with HDP and a control group. STUDY DESIGN: We recruited and obtained a complete follow-up of 19 COVID-19 pregnant patients with HDP and of 24 COVID-19 normotensive pregnant patients. Demographic, clinical and sFlt-1/PlGF ratio findings were compared with a group of 185 non COVID-19 pregnant patients with HDP and 41 non COVID normotensive patients. Findings were based on univariate analysis and on a multivariate adjusted model, and a case by case analysis of COVID-19 pregnant patients with an abnormal sFlt-1/PlGF ratio > 38 at recruitment. MAIN OUTCOME MEASURES: sFlt-1/PlGF ratio. RESULTS: We confirmed a significant higher prevalence of HDP in women affected by COVID-19 compared to control population. sFlt-1/PlGF ratio was found high in HDP patients, with and without of Sars-Cov2 infection. COVID-19 patients with worse evolution of the disease showed greater rates of obesity and other comorbidities. sFlt/PlGF ratio proved not to be helpful in the differential diagnosis of the severity of this infection. CONCLUSIONS: COVID-19 pregnant patients showed a higher prevalence of HDP compared to non COVID-19 controls, as well as higher comorbidity rates. In spite of the possible common endothelial target and damage, between Sars-Cov-2 infection and HDP, the sFlt1/PlGF ratio did not correlate with the severity of this syndrome. |
format | Online Article Text |
id | pubmed-8653398 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | International Society for the Study of Hypertension in Pregnancy. Published by Elsevier B.V. |
record_format | MEDLINE/PubMed |
spelling | pubmed-86533982021-12-08 sFlt-1/PlGF ratio in hypertensive disorders of pregnancy in patients affected by COVID-19 Soldavini, Chiara Maria Di Martino, Daniela Sabattini, Elisa Ornaghi, Sara Sterpi, Vittoria Erra, Roberta Invernizzi, Francesca Tine', Gabriele Giardini, Valentina Vergani, Patrizia Ossola, Manuela Wally Ferrazzi, Enrico Pregnancy Hypertens Article OBJECTIVES: To analyze soluble Fms-like tyrosine Kinase 1 (sFlt-1) and Placental Growth Factor (PlGF) ratio concentrations in COVID-19 pregnant patients with and without Hypertensive Disorders of Pregnancy (HDP), compared with non COVID-19 pregnant patients with HDP and a control group. STUDY DESIGN: We recruited and obtained a complete follow-up of 19 COVID-19 pregnant patients with HDP and of 24 COVID-19 normotensive pregnant patients. Demographic, clinical and sFlt-1/PlGF ratio findings were compared with a group of 185 non COVID-19 pregnant patients with HDP and 41 non COVID normotensive patients. Findings were based on univariate analysis and on a multivariate adjusted model, and a case by case analysis of COVID-19 pregnant patients with an abnormal sFlt-1/PlGF ratio > 38 at recruitment. MAIN OUTCOME MEASURES: sFlt-1/PlGF ratio. RESULTS: We confirmed a significant higher prevalence of HDP in women affected by COVID-19 compared to control population. sFlt-1/PlGF ratio was found high in HDP patients, with and without of Sars-Cov2 infection. COVID-19 patients with worse evolution of the disease showed greater rates of obesity and other comorbidities. sFlt/PlGF ratio proved not to be helpful in the differential diagnosis of the severity of this infection. CONCLUSIONS: COVID-19 pregnant patients showed a higher prevalence of HDP compared to non COVID-19 controls, as well as higher comorbidity rates. In spite of the possible common endothelial target and damage, between Sars-Cov-2 infection and HDP, the sFlt1/PlGF ratio did not correlate with the severity of this syndrome. International Society for the Study of Hypertension in Pregnancy. Published by Elsevier B.V. 2022-03 2021-12-08 /pmc/articles/PMC8653398/ /pubmed/34998223 http://dx.doi.org/10.1016/j.preghy.2021.12.001 Text en © 2021 International Society for the Study of Hypertension in Pregnancy. Published by Elsevier B.V. All rights reserved. Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active. |
spellingShingle | Article Soldavini, Chiara Maria Di Martino, Daniela Sabattini, Elisa Ornaghi, Sara Sterpi, Vittoria Erra, Roberta Invernizzi, Francesca Tine', Gabriele Giardini, Valentina Vergani, Patrizia Ossola, Manuela Wally Ferrazzi, Enrico sFlt-1/PlGF ratio in hypertensive disorders of pregnancy in patients affected by COVID-19 |
title | sFlt-1/PlGF ratio in hypertensive disorders of pregnancy in patients affected by COVID-19 |
title_full | sFlt-1/PlGF ratio in hypertensive disorders of pregnancy in patients affected by COVID-19 |
title_fullStr | sFlt-1/PlGF ratio in hypertensive disorders of pregnancy in patients affected by COVID-19 |
title_full_unstemmed | sFlt-1/PlGF ratio in hypertensive disorders of pregnancy in patients affected by COVID-19 |
title_short | sFlt-1/PlGF ratio in hypertensive disorders of pregnancy in patients affected by COVID-19 |
title_sort | sflt-1/plgf ratio in hypertensive disorders of pregnancy in patients affected by covid-19 |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8653398/ https://www.ncbi.nlm.nih.gov/pubmed/34998223 http://dx.doi.org/10.1016/j.preghy.2021.12.001 |
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