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Extensive progressive heterotopic ossification post-Covid-19 in a man

Heterotopic ossification (HO) is the formation of extraskeletal bone in muscle and soft tissues and could be genetic or non-genetic. The classic presentation of non-genetic HO is in young adults with a clear history of local trauma, surgery or prolonged immobilization after spinal cord and traumatic...

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Autores principales: Brance, María Lorena, Cóccaro, Nicolás M., Casalongue, Araceli N., Durán, Ariel, Brun, Lucas R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier Inc. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8653400/
https://www.ncbi.nlm.nih.gov/pubmed/34896358
http://dx.doi.org/10.1016/j.bone.2021.116287
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author Brance, María Lorena
Cóccaro, Nicolás M.
Casalongue, Araceli N.
Durán, Ariel
Brun, Lucas R.
author_facet Brance, María Lorena
Cóccaro, Nicolás M.
Casalongue, Araceli N.
Durán, Ariel
Brun, Lucas R.
author_sort Brance, María Lorena
collection PubMed
description Heterotopic ossification (HO) is the formation of extraskeletal bone in muscle and soft tissues and could be genetic or non-genetic. The classic presentation of non-genetic HO is in young adults with a clear history of local trauma, surgery or prolonged immobilization after spinal cord and traumatic brain injuries. Genetic HO has a significant clinical severity compared to non-genetic causes and includes fibrodysplasia ossificans progressiva (FOP). FOP is an extremely rare genetic skeletal disorder characterized by congenital malformations of the great toes and progressive heterotopic ossification that forms qualitatively normal bone in characteristic extraskeletal sites affecting skeletal muscles, fascia, tendons, and ligaments. Previously, it has been reported an association between SARS-CoV-2 infection (COVID-19) and HO or FOP exacerbation with unclear etiopathogenesis. The possible mechanisms could be prolonged immobilization and systemic inflammation. Here, we describe the case of a 55-year-old apparently healthy man who suffered from a severe SARS-CoV-2 infection after that he experienced an extensive and progressive heterotopic ossification around the shoulders, the elbows, the hip, the knees, and the ankles. Because of the clinical severity, the painful soft-tissue swelling, the progressive HO, and the bilateral congenital hallux valgus deformity, a late-onset atypical FOP was suspected. Nevertheless, no variant of clinical significance has been identified in the coding regions and splicing sites in the ACVR1 gene and no deletions and/or duplications have been identified in exonic regions.
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spelling pubmed-86534002021-12-08 Extensive progressive heterotopic ossification post-Covid-19 in a man Brance, María Lorena Cóccaro, Nicolás M. Casalongue, Araceli N. Durán, Ariel Brun, Lucas R. Bone Case Report Heterotopic ossification (HO) is the formation of extraskeletal bone in muscle and soft tissues and could be genetic or non-genetic. The classic presentation of non-genetic HO is in young adults with a clear history of local trauma, surgery or prolonged immobilization after spinal cord and traumatic brain injuries. Genetic HO has a significant clinical severity compared to non-genetic causes and includes fibrodysplasia ossificans progressiva (FOP). FOP is an extremely rare genetic skeletal disorder characterized by congenital malformations of the great toes and progressive heterotopic ossification that forms qualitatively normal bone in characteristic extraskeletal sites affecting skeletal muscles, fascia, tendons, and ligaments. Previously, it has been reported an association between SARS-CoV-2 infection (COVID-19) and HO or FOP exacerbation with unclear etiopathogenesis. The possible mechanisms could be prolonged immobilization and systemic inflammation. Here, we describe the case of a 55-year-old apparently healthy man who suffered from a severe SARS-CoV-2 infection after that he experienced an extensive and progressive heterotopic ossification around the shoulders, the elbows, the hip, the knees, and the ankles. Because of the clinical severity, the painful soft-tissue swelling, the progressive HO, and the bilateral congenital hallux valgus deformity, a late-onset atypical FOP was suspected. Nevertheless, no variant of clinical significance has been identified in the coding regions and splicing sites in the ACVR1 gene and no deletions and/or duplications have been identified in exonic regions. Elsevier Inc. 2022-02 2021-12-08 /pmc/articles/PMC8653400/ /pubmed/34896358 http://dx.doi.org/10.1016/j.bone.2021.116287 Text en © 2021 Elsevier Inc. All rights reserved. Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.
spellingShingle Case Report
Brance, María Lorena
Cóccaro, Nicolás M.
Casalongue, Araceli N.
Durán, Ariel
Brun, Lucas R.
Extensive progressive heterotopic ossification post-Covid-19 in a man
title Extensive progressive heterotopic ossification post-Covid-19 in a man
title_full Extensive progressive heterotopic ossification post-Covid-19 in a man
title_fullStr Extensive progressive heterotopic ossification post-Covid-19 in a man
title_full_unstemmed Extensive progressive heterotopic ossification post-Covid-19 in a man
title_short Extensive progressive heterotopic ossification post-Covid-19 in a man
title_sort extensive progressive heterotopic ossification post-covid-19 in a man
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8653400/
https://www.ncbi.nlm.nih.gov/pubmed/34896358
http://dx.doi.org/10.1016/j.bone.2021.116287
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