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COVID-19 and thrombotic complications—the role of anticoagulants, antiplatelets and thrombolytics

Coronavirus disease 2019 (COVID-19) is a global pandemic the world is dealing with currently. Clinical evidences suggest that the patients are predisposed to both venous and arterial thrombotic complications. This is because of severe inflammatory responses, injury to endothelium and activation of p...

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Autores principales: Khandelwal, Gaurav, Ray, Avik, Sethi, Samdish, Harikrishnan, H. K., Khandelwal, Chaitanya, Sadasivam, Balakrishnan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Wolters Kluwer - Medknow 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8653484/
https://www.ncbi.nlm.nih.gov/pubmed/34934647
http://dx.doi.org/10.4103/jfmpc.jfmpc_1297_20
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author Khandelwal, Gaurav
Ray, Avik
Sethi, Samdish
Harikrishnan, H. K.
Khandelwal, Chaitanya
Sadasivam, Balakrishnan
author_facet Khandelwal, Gaurav
Ray, Avik
Sethi, Samdish
Harikrishnan, H. K.
Khandelwal, Chaitanya
Sadasivam, Balakrishnan
author_sort Khandelwal, Gaurav
collection PubMed
description Coronavirus disease 2019 (COVID-19) is a global pandemic the world is dealing with currently. Clinical evidences suggest that the patients are predisposed to both venous and arterial thrombotic complications. This is because of severe inflammatory responses, injury to endothelium and activation of platelets leading to increased coagulation. Additionally, individuals who are already receiving antithrombotic drug therapy for various cardiovascular diseases and complications might contract the disease in which case, attention should be given to the choice and duration of the therapy besides close monitoring of biochemical blood parameters. Herein, we review the incidences of thrombotic complications and their outcomes in COVID-19 patients as reported till date, while understanding the prophylactic and therapeutic roles of anticoagulants, antiplatelets and thrombolytics in the management of this severe viral respiratory illness.
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spelling pubmed-86534842021-12-20 COVID-19 and thrombotic complications—the role of anticoagulants, antiplatelets and thrombolytics Khandelwal, Gaurav Ray, Avik Sethi, Samdish Harikrishnan, H. K. Khandelwal, Chaitanya Sadasivam, Balakrishnan J Family Med Prim Care Review Article Coronavirus disease 2019 (COVID-19) is a global pandemic the world is dealing with currently. Clinical evidences suggest that the patients are predisposed to both venous and arterial thrombotic complications. This is because of severe inflammatory responses, injury to endothelium and activation of platelets leading to increased coagulation. Additionally, individuals who are already receiving antithrombotic drug therapy for various cardiovascular diseases and complications might contract the disease in which case, attention should be given to the choice and duration of the therapy besides close monitoring of biochemical blood parameters. Herein, we review the incidences of thrombotic complications and their outcomes in COVID-19 patients as reported till date, while understanding the prophylactic and therapeutic roles of anticoagulants, antiplatelets and thrombolytics in the management of this severe viral respiratory illness. Wolters Kluwer - Medknow 2021-10 2021-11-05 /pmc/articles/PMC8653484/ /pubmed/34934647 http://dx.doi.org/10.4103/jfmpc.jfmpc_1297_20 Text en Copyright: © 2021 Journal of Family Medicine and Primary Care https://creativecommons.org/licenses/by-nc-sa/4.0/This is an open access journal, and articles are distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as appropriate credit is given and the new creations are licensed under the identical terms.
spellingShingle Review Article
Khandelwal, Gaurav
Ray, Avik
Sethi, Samdish
Harikrishnan, H. K.
Khandelwal, Chaitanya
Sadasivam, Balakrishnan
COVID-19 and thrombotic complications—the role of anticoagulants, antiplatelets and thrombolytics
title COVID-19 and thrombotic complications—the role of anticoagulants, antiplatelets and thrombolytics
title_full COVID-19 and thrombotic complications—the role of anticoagulants, antiplatelets and thrombolytics
title_fullStr COVID-19 and thrombotic complications—the role of anticoagulants, antiplatelets and thrombolytics
title_full_unstemmed COVID-19 and thrombotic complications—the role of anticoagulants, antiplatelets and thrombolytics
title_short COVID-19 and thrombotic complications—the role of anticoagulants, antiplatelets and thrombolytics
title_sort covid-19 and thrombotic complications—the role of anticoagulants, antiplatelets and thrombolytics
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8653484/
https://www.ncbi.nlm.nih.gov/pubmed/34934647
http://dx.doi.org/10.4103/jfmpc.jfmpc_1297_20
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