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Association study of a genetic variant in the long intergenic noncoding RNA (linc01080) with schizophrenia in Han Chinese

BACKGROUND: Schizophrenia is currently considered to be a polygene-related disease with unknown etiology. This research will verify whether the single nucleotide polymorphism (SNP) of the long intergenic noncoding RNA01080 (linc01080) contributes to the susceptibility and phenotypic heterogeneity of...

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Autores principales: Qi, Yi, Wei, Yaxue, Yu, Fengyan, Lin, Qianxing, Yin, Jingwen, Fu, Jiawu, Xiong, Susu, Lv, Dong, Dai, Zhun, Peng, Qian, Wang, Ying, Zhang, Dandan, Wang, Lulu, Ye, Xiaoqing, Lin, Zhixiong, Lin, Juda, Ma, Guoda, Li, Keshen, Luo, Xudong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8653569/
https://www.ncbi.nlm.nih.gov/pubmed/34879837
http://dx.doi.org/10.1186/s12888-021-03623-2
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author Qi, Yi
Wei, Yaxue
Yu, Fengyan
Lin, Qianxing
Yin, Jingwen
Fu, Jiawu
Xiong, Susu
Lv, Dong
Dai, Zhun
Peng, Qian
Wang, Ying
Zhang, Dandan
Wang, Lulu
Ye, Xiaoqing
Lin, Zhixiong
Lin, Juda
Ma, Guoda
Li, Keshen
Luo, Xudong
author_facet Qi, Yi
Wei, Yaxue
Yu, Fengyan
Lin, Qianxing
Yin, Jingwen
Fu, Jiawu
Xiong, Susu
Lv, Dong
Dai, Zhun
Peng, Qian
Wang, Ying
Zhang, Dandan
Wang, Lulu
Ye, Xiaoqing
Lin, Zhixiong
Lin, Juda
Ma, Guoda
Li, Keshen
Luo, Xudong
author_sort Qi, Yi
collection PubMed
description BACKGROUND: Schizophrenia is currently considered to be a polygene-related disease with unknown etiology. This research will verify whether the single nucleotide polymorphism (SNP) of the long intergenic noncoding RNA01080 (linc01080) contributes to the susceptibility and phenotypic heterogeneity of schizophrenia, with a view to providing data support for the prevention and individualized treatment of this disease. METHOD: The SNP rs7990916 in linc01080 were genotyped in 1139 schizophrenic and 1039 controls in a Southern Chinese Han population by the improved multiplex ligation detection reaction (imLDR) technique. Meanwhile, we assessed and analyzed the association between this SNP and schizophrenics’ clinical symptoms, and the cognitive function. RESULT: There was no significant difference in genotype distribution, allele frequency distribution, gender stratification analysis between the two groups. However, the SNP of rs7990916 was significantly associated with the age of onset in patients with schizophrenia (P = 8.22E-07), patients with T allele had earlier onset age compared with CC genotype carriers. In terms of cognitive function, patients with T allele scored lower than CC genotype carriers in the Tower of London score and symbol coding score in the Brief assessment of Cognition (BACS), and the difference was statistically significant (P = 0.014, P = 0.022, respectively). CONCLUSION: Our data show for the first time that linc01080 polymorphism may affect the age of onset and neurocognitive function in patients with schizophrenia.
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spelling pubmed-86535692021-12-08 Association study of a genetic variant in the long intergenic noncoding RNA (linc01080) with schizophrenia in Han Chinese Qi, Yi Wei, Yaxue Yu, Fengyan Lin, Qianxing Yin, Jingwen Fu, Jiawu Xiong, Susu Lv, Dong Dai, Zhun Peng, Qian Wang, Ying Zhang, Dandan Wang, Lulu Ye, Xiaoqing Lin, Zhixiong Lin, Juda Ma, Guoda Li, Keshen Luo, Xudong BMC Psychiatry Research BACKGROUND: Schizophrenia is currently considered to be a polygene-related disease with unknown etiology. This research will verify whether the single nucleotide polymorphism (SNP) of the long intergenic noncoding RNA01080 (linc01080) contributes to the susceptibility and phenotypic heterogeneity of schizophrenia, with a view to providing data support for the prevention and individualized treatment of this disease. METHOD: The SNP rs7990916 in linc01080 were genotyped in 1139 schizophrenic and 1039 controls in a Southern Chinese Han population by the improved multiplex ligation detection reaction (imLDR) technique. Meanwhile, we assessed and analyzed the association between this SNP and schizophrenics’ clinical symptoms, and the cognitive function. RESULT: There was no significant difference in genotype distribution, allele frequency distribution, gender stratification analysis between the two groups. However, the SNP of rs7990916 was significantly associated with the age of onset in patients with schizophrenia (P = 8.22E-07), patients with T allele had earlier onset age compared with CC genotype carriers. In terms of cognitive function, patients with T allele scored lower than CC genotype carriers in the Tower of London score and symbol coding score in the Brief assessment of Cognition (BACS), and the difference was statistically significant (P = 0.014, P = 0.022, respectively). CONCLUSION: Our data show for the first time that linc01080 polymorphism may affect the age of onset and neurocognitive function in patients with schizophrenia. BioMed Central 2021-12-08 /pmc/articles/PMC8653569/ /pubmed/34879837 http://dx.doi.org/10.1186/s12888-021-03623-2 Text en © The Author(s) 2021 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
spellingShingle Research
Qi, Yi
Wei, Yaxue
Yu, Fengyan
Lin, Qianxing
Yin, Jingwen
Fu, Jiawu
Xiong, Susu
Lv, Dong
Dai, Zhun
Peng, Qian
Wang, Ying
Zhang, Dandan
Wang, Lulu
Ye, Xiaoqing
Lin, Zhixiong
Lin, Juda
Ma, Guoda
Li, Keshen
Luo, Xudong
Association study of a genetic variant in the long intergenic noncoding RNA (linc01080) with schizophrenia in Han Chinese
title Association study of a genetic variant in the long intergenic noncoding RNA (linc01080) with schizophrenia in Han Chinese
title_full Association study of a genetic variant in the long intergenic noncoding RNA (linc01080) with schizophrenia in Han Chinese
title_fullStr Association study of a genetic variant in the long intergenic noncoding RNA (linc01080) with schizophrenia in Han Chinese
title_full_unstemmed Association study of a genetic variant in the long intergenic noncoding RNA (linc01080) with schizophrenia in Han Chinese
title_short Association study of a genetic variant in the long intergenic noncoding RNA (linc01080) with schizophrenia in Han Chinese
title_sort association study of a genetic variant in the long intergenic noncoding rna (linc01080) with schizophrenia in han chinese
topic Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8653569/
https://www.ncbi.nlm.nih.gov/pubmed/34879837
http://dx.doi.org/10.1186/s12888-021-03623-2
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