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Clinical Spectrum of Cutaneous Tuberculosis in Central India: A Retrospective Study

INTRODUCTION: Extrapulmonary tuberculosis (EPTB) is a significant health problem in both developing and developed countries. In India, cutaneous TB constitutes about 0.1% to 2% of the total skin diseases attending outpatients. AIM AND OBJECTIVES: To study the clinical spectrum and therapeutic outcom...

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Autores principales: Supekar, Bhagyashree B., Wankhade, Vaishali H., Singh, Rajesh P., Ghanate, Tejal D., Bhat, Dharitri
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Wolters Kluwer - Medknow 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8653751/
https://www.ncbi.nlm.nih.gov/pubmed/34934717
http://dx.doi.org/10.4103/2229-5178.330811
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author Supekar, Bhagyashree B.
Wankhade, Vaishali H.
Singh, Rajesh P.
Ghanate, Tejal D.
Bhat, Dharitri
author_facet Supekar, Bhagyashree B.
Wankhade, Vaishali H.
Singh, Rajesh P.
Ghanate, Tejal D.
Bhat, Dharitri
author_sort Supekar, Bhagyashree B.
collection PubMed
description INTRODUCTION: Extrapulmonary tuberculosis (EPTB) is a significant health problem in both developing and developed countries. In India, cutaneous TB constitutes about 0.1% to 2% of the total skin diseases attending outpatients. AIM AND OBJECTIVES: To study the clinical spectrum and therapeutic outcome in cutaneous TB. MATERIAL AND METHODS: Medical records of diagnosed cases of cutaneous TB from June 2015 to June 2018 were analyzed retrospectively with respect to epidemiology, clinical features, investigations, and treatment outcome. Statistical analysis was done using mean, median, and proportion. RESULTS: Fifty-two patients with cutaneous TB were recruited. Females (61.53%) outnumbered males. The most common age group affected was 21–30 years (32.69%) followed by 41–50 years (30%). Lupus vulgaris was the most common clinical type with head and neck being the most common site of involvement. Mantoux positivity was reported in 67.30% of patients while raised ESR in 71.15% of patients. Two patients had serology positive for HIV. Conclusive evidence of TB on histopathology was reported in 86.53%. Excellent response was observed in cases of lupus vulgaris, scrofuloderma, and tuberculosis verrucosa cutis. CONCLUSION: This retrospective analysis emphasizes the importance of clinicopathological correlation and therapeutic response in cutaneous TB. Although positive results of ESR, Mantoux reactivity, and TB cultures facilitate the clinical diagnosis, negative results should not exclude the diagnosis of cutaneous TB. This prominent case detection in the era of the Revised National TB Control Programme, in short period of time signifies health burden of cutaneous TB in this part of Maharashtra.
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spelling pubmed-86537512021-12-20 Clinical Spectrum of Cutaneous Tuberculosis in Central India: A Retrospective Study Supekar, Bhagyashree B. Wankhade, Vaishali H. Singh, Rajesh P. Ghanate, Tejal D. Bhat, Dharitri Indian Dermatol Online J Original Article INTRODUCTION: Extrapulmonary tuberculosis (EPTB) is a significant health problem in both developing and developed countries. In India, cutaneous TB constitutes about 0.1% to 2% of the total skin diseases attending outpatients. AIM AND OBJECTIVES: To study the clinical spectrum and therapeutic outcome in cutaneous TB. MATERIAL AND METHODS: Medical records of diagnosed cases of cutaneous TB from June 2015 to June 2018 were analyzed retrospectively with respect to epidemiology, clinical features, investigations, and treatment outcome. Statistical analysis was done using mean, median, and proportion. RESULTS: Fifty-two patients with cutaneous TB were recruited. Females (61.53%) outnumbered males. The most common age group affected was 21–30 years (32.69%) followed by 41–50 years (30%). Lupus vulgaris was the most common clinical type with head and neck being the most common site of involvement. Mantoux positivity was reported in 67.30% of patients while raised ESR in 71.15% of patients. Two patients had serology positive for HIV. Conclusive evidence of TB on histopathology was reported in 86.53%. Excellent response was observed in cases of lupus vulgaris, scrofuloderma, and tuberculosis verrucosa cutis. CONCLUSION: This retrospective analysis emphasizes the importance of clinicopathological correlation and therapeutic response in cutaneous TB. Although positive results of ESR, Mantoux reactivity, and TB cultures facilitate the clinical diagnosis, negative results should not exclude the diagnosis of cutaneous TB. This prominent case detection in the era of the Revised National TB Control Programme, in short period of time signifies health burden of cutaneous TB in this part of Maharashtra. Wolters Kluwer - Medknow 2021-11-22 /pmc/articles/PMC8653751/ /pubmed/34934717 http://dx.doi.org/10.4103/2229-5178.330811 Text en Copyright: © 2021 Indian Dermatology Online Journal https://creativecommons.org/licenses/by-nc-sa/4.0/This is an open access journal, and articles are distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as appropriate credit is given and the new creations are licensed under the identical terms.
spellingShingle Original Article
Supekar, Bhagyashree B.
Wankhade, Vaishali H.
Singh, Rajesh P.
Ghanate, Tejal D.
Bhat, Dharitri
Clinical Spectrum of Cutaneous Tuberculosis in Central India: A Retrospective Study
title Clinical Spectrum of Cutaneous Tuberculosis in Central India: A Retrospective Study
title_full Clinical Spectrum of Cutaneous Tuberculosis in Central India: A Retrospective Study
title_fullStr Clinical Spectrum of Cutaneous Tuberculosis in Central India: A Retrospective Study
title_full_unstemmed Clinical Spectrum of Cutaneous Tuberculosis in Central India: A Retrospective Study
title_short Clinical Spectrum of Cutaneous Tuberculosis in Central India: A Retrospective Study
title_sort clinical spectrum of cutaneous tuberculosis in central india: a retrospective study
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8653751/
https://www.ncbi.nlm.nih.gov/pubmed/34934717
http://dx.doi.org/10.4103/2229-5178.330811
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