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Early Drug Discovery and Development of Novel Cancer Therapeutics Targeting DNA Polymerase Eta (POLH)

Polymerase eta (or Pol η or POLH) is a specialized DNA polymerase that is able to bypass certain blocking lesions, such as those generated by ultraviolet radiation (UVR) or cisplatin, and is deployed to replication foci for translesion synthesis as part of the DNA damage response (DDR). Inherited de...

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Detalles Bibliográficos
Autores principales:	Wilson, David M., Duncton, Matthew A. J., Chang, Caleb, Lee Luo, Christie, Georgiadis, Taxiarchis M., Pellicena, Patricia, Deacon, Ashley M., Gao, Yang, Das, Debanu
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2021
Materias:	Oncology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8653755/ https://www.ncbi.nlm.nih.gov/pubmed/34900730 http://dx.doi.org/10.3389/fonc.2021.778925

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